Trends in Genetics
Volume 33, Issue 12, December 2017, Pages 895-897
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SAMHD1 Sheds Moonlight on DNA Double-Strand Break Repair

https://doi.org/10.1016/j.tig.2017.09.007Get rights and content
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SAMHD1 (sterile α motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks (DSBs) by promoting recruitment of C-terminal binding protein interacting protein (CTIP), a DNA-end resection factor, to damaged DNA. These findings could benefit anticancer treatment.

Keywords

SAMHD1
DNA double-strand breaks
homologous recombination
DNA-end resection
CTIP
cancer

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