Importance of viral genomic composition in modulating glycoprotein content on the surface of influenza virus particles
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Research Highlights
► Cryo-EM and reverse genetics as tools to investigate determinants of influenza morphology. ► Surface GP density influenced by both the virus subtype and the mode of production. ► Viral genomic composition not the only determinant of viral size and shape... ► ...but important in determining surface GP density and possibly HA/NA ratio. ► PB1/PB2 and HA gene segments strongly influence surface GP spike density.
Keywords
Influenza
Orthomyxoviridae
Viral glycoprotein
Haemagglutinin (HA)
Neuraminidase (NA)
Cryo-electron microscopy (cryo-EM)
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Authors VM and OT contributed equally to this work
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