WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways
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Highlights
► WT1 promoted epicardial EMT through Wnt and retinoic acid signaling pathways. ► WT1 stimulated canonical Wnt/β-catenin signaling by upregulating LEF1 and β-catenin. ► WT1 stimulated epicardial expression of non-canonical Wnt5a. ► Epicardial expression of Raldh2, essential for retinoic acid signaling, requires Wt1.
Abbreviations
EMT
Epithelial to mesenchymal transition
EPDC
Epicardium-derived cell
EPI
FACS-sorted cells by GFP expression in Wt1GFPCre heart. Predominantly epicardial cells, plus the EPDC subset that continues to express Wt1 or has perdurance of GFP expression
WT1KO
Wt1 knockout
Ctnnb1EPI
Ctnnb1 knockout by Wt1CreERT2 with Tam given at E10.5
ATRA
All-trans retinoic acid
Tam
Tamoxifen
qRTPCR
Quantitative reverse transcription polymerase chain reaction
Keywords
Mesothelium
Epicardium
Epithelial to mesenchymal transition
WT1
Wnt/β-catenin signaling
Retinoic acid signaling
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