The FGD homologue EXC-5 regulates apical trafficking in C. elegans tubules
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Highlights
► Loss of EXC-5 allows narrow tubules to swell into fluid-filled cysts. ► Loss of EXC-5 causes accumulation of early endosome marker EEA-1 in cysts. ► Sorting endosome marker RME-1 is depleted in cysts. ► Buildup of EEA-1 precedes collapse of tubules into cysts. ► CDC-42 activity partially rescues loss of EXC-5, phenocopies EXC-5 overexpression.
Keywords
Charcot–Marie–Tooth Syndrome
FGD
EEA1
RME-1
Rab
CDC42
Endosome recycling
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