Pushing the envelope of retinal ganglion cell genesis: Context dependent function of Math5 (Atoh7)
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Highlights
► Gain-of-function test of Math5 bHLH factor action in mice. ► BAC and conventional Crx>Math5-ires-Cre transgenes, with Crx>Cre controls. ► Temporal shift in retinal ganglion cell (RGC) birthdates but no change in overall time envelope. ► Math5 is not the sole determinant of RGC fate competence. ► Heterochronic rescue of RGC agenesis phenotype in Math5 KO mice, with axonal pathfinding defects.
Keywords
Retinal ganglion cell (RGC)
Math5
Atoh7
Optic nerve
Basic helix-loop-helix (bHLH)
Crx
Cell fate specification
Cone–rod homeodomain
Atonal
BAC transgene
Retinal explants
Axon pathfinding
Heterochronic
Transgene rescue
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