An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation
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Highlights
► Reduced sympathetic innervation of peripheral targets in Wnt5a conditional mutants. ► Wnt5a ablation in peripheral neurons does not perturb overall tissue patterning. ► An autocrine Wnt5a-Ror signaling loop in sympathetic axons directs axon branching.
Keywords
Autocrine Wnt signaling
Axon branching
Sympathetic neural development
Conditional mouse mutants
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Present address: Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
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