Molecular Therapy
Volume 27, Issue 4, 10 April 2019, Pages 710-728
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Review
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

https://doi.org/10.1016/j.ymthe.2019.02.012Get rights and content
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mRNA has broad potential as a therapeutic. Current clinical efforts are focused on vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical translation of mRNA therapeutics has been made possible through advances in the design of mRNA manufacturing and intracellular delivery methods. However, broad application of mRNA is still limited by the need for improved delivery systems. In this review, we discuss the challenges for clinical translation of mRNA-based therapeutics, with an emphasis on recent advances in biomaterials and delivery strategies, and we present an overview of the applications of mRNA-based delivery for protein therapy, gene editing, and vaccination.

Keywords

mRNA delivery
mRNA vaccine
CRISPR
gene editing
gene therapy
protein replacement
biomaterials
mRNA nanoparticles
lipid nanoparticles
clinical trial

Cited by (0)

6

These authors contributed equally to this work.