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Acceleration of hippocampal atrophy in a non-demented elderly population: the SNAC-K study

Published online by Cambridge University Press:  04 December 2009

Yi Zhang*
Affiliation:
Department of Clinical Science, Intervention and Technology, Division of Radiology, Karolinska Institutet, Stockholm, Sweden
Chengxuan Qiu
Affiliation:
Department of Neurobiology, Care Sciences and Society, Division of Aging Research Center, Karolinska Institutet, Stockholm, Sweden
Olof Lindberg
Affiliation:
Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatric, Karolinska Institutet, Huddinge, Stockholm, Sweden
Lena Bronge
Affiliation:
Department of Clinical Science, Intervention and Technology, Division of Radiology, Karolinska Institutet, Stockholm, Sweden Department of MRI in Sabbatsberg, Aleris Diagnostics, Stockholm, Sweden
Peter Aspelin
Affiliation:
Department of Clinical Science, Intervention and Technology, Division of Radiology, Karolinska Institutet, Stockholm, Sweden
Lars Bäckman
Affiliation:
Department of Neurobiology, Care Sciences and Society, Division of Aging Research Center, Karolinska Institutet, Stockholm, Sweden
Laura Fratiglioni
Affiliation:
Department of Neurobiology, Care Sciences and Society, Division of Aging Research Center, Karolinska Institutet, Stockholm, Sweden
Lars-Olof Wahlund
Affiliation:
Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatric, Karolinska Institutet, Huddinge, Stockholm, Sweden
*
Correspondence should be addressed to: Yi Zhang, Department of NVS, NOVUM, Plan 5, Stockholm, Sweden. Phone: +46 8 585 86193; Fax: +46 8 585 85470. Email: yi.zhang@ki.se.

Abstract

Background: Brain atrophy in Alzheimer's disease (AD) includes not only AD-specific brain atrophy but also the atrophy induced by normal aging. Atrophy of the hippocampus has been one diagnostic marker of AD, but it was also found to emerge in healthy adults, along with increasing age. It was reported that the important age when age-related shrinkage of the hippocampus starts was around the mid-40s. The aim is to study the aging atrophy speed and acceleration of brain atrophy in a cross-sectional database, to identify the age at which acceleration of hippocampal atrophy starts in non-demented elderly persons.

Methods: 544 subjects (aged 60–97 years; 318 female and 226 male) were recruited into the MRI study by using a subsample of an epidemiological sample of 3363 healthy non-demented elderly people (over 60 years of age). Hippocampus and ventricle sizes were measured.

Results: The normalized volumes (by intracranial volume, ICV) of the hippocampus in males were smaller than those in females. The right hippocampus was larger than the left. The expansion of the lateral ventricles (2.80% per year in males, 2.95% in females) and third ventricle (1.58% and 2.28%, respectively) was more marked than the hippocampal shrinkage (0.68% and 0.79%, respectively). The suggested age at which acceleration of hippocampal atrophy starts is 72 years.

Conclusions: Males present smaller hippocampus volumes (normalized by ICV) than females; however, females are more vulnerable to hippocampal atrophy in a non-demented elderly population. An acceleration of hippocampal atrophy may emerge and start around 72 years of age in a non-demented elderly population.

Type
2009 IPA JUNIOR RESEARCH AWARDS – SECOND-PRIZE WINNER
Copyright
Copyright © International Psychogeriatric Association 2009

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References

Barnes, L. L., Wilson, R. S., Bienias, J. L., Schneider, J. A., Evans, D. A. and Bennett, D. A. (2005). Sex differences in the clinical manifestations of Alzheimer disease pathology. Archives of General Psychiatry, 62, 685691.Google Scholar
Braak, H. and Braak, E. (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathology, 82, 239259.Google Scholar
Braak, H. and Braak, E. (1997). Staging of Alzheimer-related cortical destruction. International Psychogeriatrics, 9 (Suppl. 1), 257261; discussion 269–272.Google Scholar
Callen, D. J., Black, S. E., Gao, F., Caldwell, C. B. and Szalai, J. P. (2001). Beyond the hippocampus: MRI volumetry confirms widespread limbic atrophy in AD. Neurology, 57, 16691674.Google Scholar
Carne, R. P., Vogrin, S., Litewka, L. and Cook, M. J. (2006). Cerebral cortex: an MRI-based study of volume and variance with age and sex. Journal of Clinical Neuroscience, 13, 6072.Google Scholar
Coffey, C. E. et al. (1992). Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imaging. Neurology, 42, 527536.Google Scholar
Convit, A. et al. (1997). Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease. Neurobiology of Aging, 18, 131138.Google Scholar
De Santi, S. et al. (2001). Hippocampal formation glucose metabolism and volume losses in MCI and AD. Neurobiology of Aging, 22, 529539.Google Scholar
Dekaban, A. S. (1978). Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Annals of Neurology, 4, 345356.Google Scholar
Du, A. T. et al. (2001). Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 71, 441447.Google Scholar
Gomez-Isla, T., Price, J. L., McKeel, D. W. Jr., Morris, J. C., Growdon, J. H. and Hyman, B. T. (1996). Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. Journal of Neuroscience, 16, 44914500.Google Scholar
Jack, C. R. Jr., et al. (2000). Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology, 55, 484489.Google Scholar
Jernigan, T. L. and Gamst, A. C. (2005). Changes in volume with age: consistency and interpretation of observed effects. Neurobiology of Aging, 26, 12711274; discussion 1275–1278.Google Scholar
Jorm, A. F., Korten, A. E. and Henderson, A. S. (1987). The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatrica Scandinavica, 76, 465479.Google Scholar
Laakso, M. P. et al. (1996). Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: An MRI study. Neurology, 46, 678681.Google Scholar
Lupien, S. J. et al. (2007). Hippocampal volume is as variable in young as in older adults: implications for the notion of hippocampal atrophy in humans. Neuroimage, 34, 479485.Google Scholar
Muller, M. J. et al. (2005). Functional implications of hippocampal volume and diffusivity in mild cognitive impairment. Neuroimage, 28, 10331042.Google Scholar
Pantel, J. et al. (2000). A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy. Hippocampus, 10, 752758.Google Scholar
Paradise, M., Cooper, C. and Livingston, G. (2009). Systematic review of the effect of education on survival in Alzheimer's disease. International Psychogeriatrics, 21, 2532.Google Scholar
Pennanen, C. et al. (2004). Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiology of Aging, 25, 303310.Google Scholar
Pruessner, J. C., Collins, D. L., Pruessner, M. and Evans, A. C. (2001). Age and gender predict volume decline in the anterior and posterior hippocampus in early adulthood. Journal of Neuroscience, 21, 194200.Google Scholar
Raz, N., Gunning-Dixon, F., Head, D., Rodrigue, K. M., Williamson, A. and Acker, J. D. (2004). Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume. Neurobiology of Aging, 25, 377396.Google Scholar
Sheline, Y. I. et al. (1996). Stereological MRI volumetry of the frontal lobe. Psychiatry Research, 67, 203214.Google Scholar
Tang, Y., Whitman, G. T., Lopez, I. and Baloh, R. W. (2001). Brain volume changes on longitudinal magnetic resonance imaging in normal older people. Journal of Neuroimaging, 11, 393400.Google Scholar
Thompson, P. M. et al. (2003). Dynamics of gray matter loss in Alzheimer's disease. Journal of Neuroscience, 23, 9941005.Google Scholar
Thompson, P. M. et al. (2004). Mapping hippocampal and ventricular change in Alzheimer disease. Neuroimage, 22, 17541766.Google Scholar
Thompson, P. M. et al. (2007). Tracking Alzheimer's disease. Annals of the New York Academy of Science, 1097, 183214.Google Scholar
Wahlund, L. O., Julin, P., Johansson, S. E. and Scheltens, P. (2000). Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging in dementia: a comparative study. Journal of Neurology, Neurosurgery and Psychiatry, 69, 630635.Google Scholar
Wu, C. C. et al. (2002). Brain structure and cognition in a community sample of elderly Latinos. Neurology, 59, 383391.Google Scholar