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Pilot Clinical Trial of NT-3 in CMT1A Patients

Published online by Cambridge University Press:  31 May 2006

Zarife Sahenk
Zarife Sahenk
Affiliation:
Department of Neurology and Pediatrics, The Ohio State University, Columbus Children's Research Institute, Neuromuscular program, Columbus, OH, USA; Email: sahenkz@ccri.net
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Abstract

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Keywords

CMT diseaseNT-3regenerationSchwann cell
Type
Review Article
Information
Progress in Neurotherapeutics and Neuropsychopharmacology , Volume 2 , Issue 1 , March 2007 , pp. 97 - 108
Copyright
© 2007 Cambridge University Press

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References

Boyd, J.G., & Gordon, T. (2003). Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Molecular Neurobiology, 27(3), 277–324.Google Scholar
Dyck, P.J., Sherman, W.R., Hallcher, L.M., et al. (1980). Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry. Annals of Neurology, 8(6), 590–596.Google Scholar
Dyck, P.J., Litchy, W.J., Lehman, K.A., Hokanson, J.L., Low, P.A., & O'Brien, P.C. (1995). Variables influencing neuropathic endpoints: the Rochester Diabetic Neuropathy Study of Healthy Subjects. Neurology, 45(6), 1115–1121.Google Scholar
Frostick, S.P., Yin, Q., & Kemp, G.J. (1998). Schwann cells, neurotrophic factors, and peripheral nerve regeneration. Microsurgery, 18(7), 397–405.Google Scholar
Li, H., Terengi, G., & Hall, S.M. (1997). Effects of delayed re-innervation on the expression of c-erbB receptors by chronically denervated rat Schwann cells in vivo. Glia, 20, 333–347.Google Scholar
Lobsiger, C.S., Schweitzer, B., Taylor, V., & Suter, U. (2000). Platelet-derived growth factor-BB supports the survival of cultured rat Schwann cell precursors in synergy with neurotrophin-3. Glia, 30(3), 290–300.Google Scholar
Martina, I.S., van Koningsveld, R., Schmitz, P.I., van der Meche, F.G., & van Doorn, P.A. (1998). Measuring vibration threshold with a graduated tuning fork in normal aging and in patients with polyneuropathy. European Inflammatory Neuropathy Cause and Treatment (INCAT) group. Journal of Neurology Neurosurgery and Psychiatry, 65(5), 743–747.Google Scholar
Meier, C., Parmantier, E., Brennan, A., Mirsky, R., & Jessen, K.R. (1999). Developing Schwann cells acquire the ability to survive without axons by establishing an autocrine circuit involving insulin-like growth factor, neurotrophin-3, and platelet-derived growth factor-BB. Journal of Neuroscience, 19, 3847–3859.Google Scholar
Mirsky, R., Jessen, K.R., Brennan, A., et al. (2002). Schwann cells as regulators of nerve development. Journal of Physiology Paris, 96(1–2), 17–24.Google Scholar
Mohiuddin, L., Fernandez, K., Tomlinson, D.R., & Fernyhough, P. (1995). Nerve growth factor and neurotrophin-3 enhance neurite outgrowth and up-regulate the levels of messenger RNA for growth-associated protein GAP-43 and T alpha 1 alpha-tubulin in cultured adult rat sensory neurones. Neuroscience Letter, 185(1), 20–23.Google Scholar
Oya, T., Zhao, Y.L., Takagawa, K., et al. (2002). Platelet-derived growth factor-b expression induced after rat peripheral nerve injuries. Glia, 38(4), 303–312.Google Scholar
Sahenk, Z., Chen, L., & Mendell, J.R. (1999). Effects of PMP22 duplication and deletions on the axonal cytoskeleton [see comments]. Annals of Neurology, 45, 16–24.Google Scholar
Sahenk, Z., Serrano-Munuera, C., Chen, L., Kakabadze, I., & Najagara, H.N. (2003). Evidence for impaired axonal regeneration in PMP22 duplication: studies in nerve xenografts. Journal of the Peripheral Nervous System, 8(2), 116–127.Google Scholar
Sahenk, Z., Nagaraja, H., McCracken, B.S., King, W.M., Freimer, M.L., Cederbaum, J.M., & Mendell, J.R. (2005). Neurotrophin-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients. Neurology, 54, 681–689.Google Scholar
Sulaiman, O.A., & Gordon, T. (2000). Effects of short and long term Schwann cell denervation on peripheral nerve regeneration, myelination and size. Glia, 32, 234–246.Google Scholar
Sunderland, S. (1952). Factors influencing the course of regeneration and quality of recovery after nerve suture. Brain, 75, 19–54.Google Scholar
Sterne, G.D., Brown, R.A., Green, C.J., & Terenghi, G. (1997). Neurotrophin-3 delivered locally via fibronectin mats enhances peripheral nerve regeneration. European Journal of Neuroscience, 9(7), 1388–1396.Google Scholar
Syroid, D.E., Zorick, T.S., Arbet-Engels, C., Kilpatrick, T.J., Eckhart, W., & Lemke, G. (1999). A role for insulin-like growth factor-I in the regulation of Schwann cell survival. Journal of Neuroscience, 19, 2059–2068.Google Scholar