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Role of Adhesion Molecules in Activation Signaling in T Lymphocytes

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Abstract

The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell–cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival.

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Authors and Affiliations

  1. Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Molecular Medicine, New York University School of Medicine, 540 First Avenue, 5th Floor, Lab 5, New York, New York, 10016

    Michael L. Dustin

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Dustin, M.L. Role of Adhesion Molecules in Activation Signaling in T Lymphocytes. J Clin Immunol 21, 258–263 (2001). https://doi.org/10.1023/A:1010927208180

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