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Vascular–Platelet and Plasma Hemostasis Regulators from Bloodsucking Animals

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Abstract

Saliva of bloodsuckers (leeches, insects, ticks, vampire bats) contains various regulators of some hemostatic stages. This review summarizes information on their structural characteristics and mechanisms of action. Most bloodsuckers are shown to inhibit vascular–platelet hemostasis by blocking collagen induced platelet adhesion/aggregation. Plasma hemostasis is inhibited by blocking activation of factor X or factor Xa directly.

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REFERENCES

  1. Markwardt, F. (1996) Clin. Appl. Thrombosis/Hemostasis, 2, 75-82.

    Google Scholar 

  2. Arocha-Pinango, C. L., Marchi, R., Carvajal, Z., and Guerrero, B. (1999) Blood Coagul. Fibrinol., 10, 43-68.

    Google Scholar 

  3. Zavalova, L. L., Basanova, A. V., and Baskova, I. P. (2002) Biochemistry (Moscow), 67, 135-142.

    Google Scholar 

  4. Stattil, S. J. (1999) Thromb. Haemost., 82, 318-325.

    Google Scholar 

  5. Andrews, R. K., Shen, Y., Gardiner, E. E., Dong, J., Lopez, J. A., and Bendt, M. C. (1999) Thromb. Haemost., 82, 357-364.

    Google Scholar 

  6. Baskova, I. P., Misselvits, F., and Nikonov, G. I. (1984) Byul. Eksp. Biol. Med., 97, 696-698.

    Google Scholar 

  7. Baskova, I. P., Nikonov, G. I., Mazurov, A. V., Misselvits, F., Leitin, V. L., Repin, V. S., Avdonin, P. V., and Svitina-Ulitina, I. V. (1987) Biokhimiya, 52, 1461-1468.

    Google Scholar 

  8. Monro, R., Jones, C., and Sawyer, R. (1991) Blood Coagul. Fibrinolysis, 2, 179-184.

    Google Scholar 

  9. Deckmyn, H., Stassen, J. M., Vreys, L., van Houtte, E., Sawyer, R. T., and Vermylen, J. (1995) Blood, 85, 712-719.

    Google Scholar 

  10. Harsfalvi, J., Stassen, J., Hoylaerts, M., van Houtte, E., and Sawyer, R. (1995) Blood, 85, 705-711.

    Google Scholar 

  11. Saelman, E. V., Nieuwenhus, H. K., Hese, K. M., de Groot, P. G., Heijnen, H. F., Sage, E. H., Williams, S., McKeown, L., Gralnick, H. R., and Sixma, J. J. (1994) Blood, 83, 1244-1250.

    Google Scholar 

  12. Depraetere, H., Karekes, A., and Deckmyn, H. (1999) Thromb. Haemost., 82, 1160-1163.

    Google Scholar 

  13. Connolly, T. M., Jacobs, J. W., and Condra, C. (1992) J. Biol. Chem., 267, 6893-6898.

    Google Scholar 

  14. Keller, P. M., Schultz, L. D., Condras, C., Karczewski, J., and Connolly, T. M. (1992) J. Biol. Chem., 267, 6899-6904.

    Google Scholar 

  15. Kato, I., Kohr, W. J., and Laskowski, M. (1978) Proc. FEBS Meet., 47, 197-206.

    Google Scholar 

  16. Tschesche, H., and Kolkenbrock, H. (1984) in Chemistry of Peptides and Proteins (Voelter, W., Bayer, E., Ovchinnikov, Y. A., and Wunsch, E., eds.) Vol. 2, Walter de Gryter, Berlin, pp. 349-355.

    Google Scholar 

  17. Rigbi, M., Levy, H., Eldor, A., Iraqi, F., Tetelbaum, M., Orevi, M., Horovitz, A., and Galun, R. (1987) Comp. Biochem. Physiol., 88C, 95-98.

    Google Scholar 

  18. Orevu, M., Rigbi, M., Hy-Am, E., Matzner, Y., and Eldor, A. (1992) Prostaglandins, 43, 483-485.

    Google Scholar 

  19. Braquet, P., Tiuqui, L., and Shen, T. S. (1987) Pharmacol. Rev., 39, 97-145.

    Google Scholar 

  20. Baskova, I., Zavalova, L. L., Berezhnoy, S., Avdonin, P., Afanasjeva, G., Popov, E., and Gabbasov, Z. (2000) Platelets, 11, 83-86.

    Google Scholar 

  21. Seymour-Ulmer, J., Henzel, W. J., Nevins, B., Stults, J. T., and Lazarus, R. A. (1990) J. Biol. Chem., 265, 10143-10147.

    Google Scholar 

  22. Ruoslahti, E., and Pierschbacher, M. D. (1987) Science, 238, 491-493.

    Google Scholar 

  23. Hynes, O. (1992) Cell, 69, 11-15.

    Google Scholar 

  24. McLane, M. A., Gabbeta, J., Rao, A. K., Beviglia, L., Lazarus, R. A., and Niewiarowski, S. (1995) Thromb. Haemost., 74, 1316-1322.

    Google Scholar 

  25. Sawyer, R. T. (1986) in Leech Biology and Behavior, Vol. 2, Clarendon Press, Oxford, pp. 518-519.

    Google Scholar 

  26. Mazur, P., Henzel, W. J., Seymour, J. L., and Lazarus, R. A. (1991) Eur. J. Biochem., 202, 1073-1082.

    Google Scholar 

  27. Kresel, A. M., Wagner, G., Seymour-Ulmer, J., and Lazarus, R. A. (1994) Science, 264, 1944-1947.

    Google Scholar 

  28. Monfort, W. R., Weichel, A., and Andersen, J. F. (2000) Biochim. Biophys. Acta, 1482, 110-118.

    Google Scholar 

  29. Noeske-Jungblut, C., Kratzchmar, J., Haendler, B., Alagon, A., Possani, L., Verha, L., Donner, P., and Shleuning, W. D. (1994) J. Biol. Chem., 269, 5050-5053.

    Google Scholar 

  30. Haendler, B., Becker, A., Noeske-Jungblut, C., Kratzschmar, J., Donner, P., and Schleuning, W. D. (1995) Biochem. J., 307 (Pt. 2), 465-470.

    Google Scholar 

  31. Haendler, B., Becker, A., Noeske-Jungblut, C., Kratzschmar, J., Donner, P., and Schleuning, W. D. (1996) Blood Coagul. Fibrinolysis, 7, 183-186.

    Google Scholar 

  32. Francischetti, I. M., Ribeiro, J. M., Champagne, D., and Andersen, J. (2000) J. Biol. Chem., 275, 12639-12650.

    Google Scholar 

  33. Waxman, L., and Connolly, T. M. (1993) J. Biol. Chem., 268, 5445-5449.

    Google Scholar 

  34. Keller, P. M., Waxman, L., Arnold, B. A., Schultz, L. D., Condra, C., and Connoly, T. M. (1993) J. Biol. Chem., 268, 5450-5456.

    Google Scholar 

  35. Mant, M. J., and Parker, K. R. (1981) Br. J. Haematol., 48, 601-608.

    Google Scholar 

  36. Broze, G. Y. (1995) Blood Coagul. Fibrinolysis, 6, S7-S13.

    Google Scholar 

  37. Rojkjaer, R., and Schmaier, A. H. (1999) Immunopharma-cology, 43, 109-114.

    Google Scholar 

  38. Baskova, I. P., Khalil, S., and Nikonov, G. I. (1984) Byul. Eksp. Biol. Med., 97, 142-143.

    Google Scholar 

  39. Khalil, S. (1987) Mechanisms of thrombolysis and inhibition of blood coagulation by preparations from the medicinal leech Hirudo medicinalis: Candidate's dissertation [in Russian], Moscow State University, Moscow.

    Google Scholar 

  40. Munro, R. (1986) Leech News Lett., 1, 5-7.

    Google Scholar 

  41. Baskova, I. P., Khalil, S., Nikonov, G. I., Rabinovich, E. E., Nartikova, V. F., and Paskhina, T. S. (1988) Biokhimiya, 53, 1467-1473.

    Google Scholar 

  42. Rigbi, M., Jackson, C. M., Atamna, H., Giguzin, I., Goldlust, A., Zeelon, E., Guy, R., Kook, M., Levanon, A., Werber, M., and Panet, A. (1995) Thromb. Haemost., 73, 1306.

    Google Scholar 

  43. Zeelon, E. P., Werber, M. M., and Levanon, A. (1995) Patent USA No. 469,219.

  44. Zeelon, E. P., Werber, M. M., and Levanon, A. (1997) Patent USA No. 5,858,970.

  45. Tuszynski, G. P., Gasic, T. B., and Gasic, G. J. (1987) J. Biol. Chem., 262, 9718-9723.

    Google Scholar 

  46. Dunwiddie, C., Thornberry, N. A., Bull, H. G., Sardana, M., Friedman, P. A., Jacobs, J. W., and Simpson, E. (1989) J. Biol. Chem., 264, 16694-16699.

    Google Scholar 

  47. Theunissen, H. J., Dijkema, R., Swinkels, J. C., de Poorter, T. L., Vink, P. M., and van Dinter, T. G. (1994) Thromb. Res., 75, 41-50.

    Google Scholar 

  48. Blankenship, D. T., Brankamp, R. G., Manley, G. D., and Cardin, A. D. (1990) Biochem. Biophys. Res. Commun., 166, 1384-1389.

    Google Scholar 

  49. Brancamp, R. G., Manley, G. G., Blankenship, D. T., Bowlin, T. L., and Cardin, A. D. (1991) Blood Coagul. Fibrinolysis, 2, 161-166.

    Google Scholar 

  50. Han, J. H., Law, S. W., Kellr, P. M., Kniskern, P. J., Silberklang, M., Tung, J.-S., Gasic, T. B., Gasic, G. J., Friedman, P. A., and Ellis, R. W. (1989) Gene, 75, 47-57.

    Google Scholar 

  51. Brankamp, R. G., Sreekrishna, K., Smith, P. L., Blankenship, D. T., and Cardin, A. D. (1995) Protein Exp. Purif., 6, 813-820.

    Google Scholar 

  52. Baskova, I. P., and Zavalova, L. L. (2001) Biochemistry (Moscow), 66, 703-714.

    Google Scholar 

  53. Faria, F., Kelen, E. M., Sampaio, C. A., Bon, C., Duval, N., and Chudzinski-Tavassi, A. M. (1999) Thromb. Haemost., 82, 1469-1473.

    Google Scholar 

  54. Chopin, V., Salzet, M., Baert, J., Vandenbulcke, F., Sautiere, P. E., Kerckaert, J. P., and Malecha, J. (2000) J. Biol. Chem., 275, 32701-32707.

    Google Scholar 

  55. Stark, K. R., and James, A. A. (1995) Exp. Parasitol., 81, 321-331.

    Google Scholar 

  56. Abebe, M., Cupp, M. S., Ramberg, F. B., and Cupp, E. W. (1994) J. Med. Entomol., 31, 908-911.

    Google Scholar 

  57. Jacobs, J. W., Cupp, E. W., Sardana, M., and Friedman, P. A. (1990) Thromb. Haemost., 64, 235-238.

    Google Scholar 

  58. Abebe, M., Ribeiro, J. M., Cupp, M. S., and Cupp, E. W. (1996) J. Med. Entomol., 33, 173-176.

    Google Scholar 

  59. Isawa, H., Yuda, M., Yoneda, K., and Chinzey, Y. (2000) J. Biol. Chem., 275, 6636-6641.

    Google Scholar 

  60. Ribeiro, J. M., Schneider, M., and Guimaraes, J. A. (1995) Biochem. J., 308 (Pt. 1), 243-249.

    Google Scholar 

  61. Waxman, L., Smith, D. E., Arcuri, K. E., and Vlasuk, G. P. (1990) Science, 248, 593-596.

    Google Scholar 

  62. Jordan, S. P., Waxman, L., Smith, D. E., and Vlasuk, G. P. (1990) Biochemistry, 29, 11095-11100.

    Google Scholar 

  63. Vlasuk, G. P. (1993) Thromb. Haemost., 70, 212-216.

    Google Scholar 

  64. Limo, M. K., Voigt, W. P., Tumbo-Oeri, A. G., Njogu, R. M., and ole-MoiYoi, O. K. (1991) Exp. Parasitol., 72, 418-429.

    Google Scholar 

  65. Apitz-Castro, R., Beguin, S., Tablante, A., Bartoli, F., Holt, J. C., and Hemker, H. C. (1995) Thromb. Haemost., 73, 94-100.

    Google Scholar 

  66. Fernandez, A. Z., Tablante, A., Bartoli, F., Beguin, S., Hemker, H. C., and Apitz-Castro, R. (1998) Biochim. Biophys. Acta, 1425, 291-299.

    Google Scholar 

  67. Fernandez, A. Z., Tablante, A., Beguin, S., Hemker, H. C., and Apitz-Castro, R. (1999) Biochim. Biophys. Acta, 1434, 135-142.

    Google Scholar 

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Authors and Affiliations

  1. School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia

    A. V. Basanova & I. P. Baskova

  2. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    L. L. Zavalova

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Basanova, A.V., Baskova, I.P. & Zavalova, L.L. Vascular–Platelet and Plasma Hemostasis Regulators from Bloodsucking Animals. Biochemistry (Moscow) 67, 143–150 (2002). https://doi.org/10.1023/A:1013968618120

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