Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Defective Viral Particles and Viral Disease Processes

Abstract

Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome. Such particles are capable of specifically interfering with the growth of homologous, standard virus and may play a major part in the evolution of viral diseases.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Fenner, F., The Biology of Animal Viruses, 1, 375 (Academic Press, New York, 1968).

    Google Scholar 

  2. Fenner, F., The Biology of Animal Viruses, 2, 475 (Academic Press, New York, 1968).

    Google Scholar 

  3. Cooper, P. D., and Bellett, A. J. D., J. Gen. Microbiol., 21, 485 (1959).

    Article  CAS  Google Scholar 

  4. Henle, W., J. Immunol., 91, 145 (1963).

    CAS  PubMed  Google Scholar 

  5. Baron, S., Medical Virology, 1, 77 (1967).

    CAS  Google Scholar 

  6. Von Magnus, P., Adv. Virus Res., 2, 59 (1954).

    Article  CAS  Google Scholar 

  7. Ada, G. L., and Perry, B. T., J. Gen. Microbiol., 14, 623 (1958).

    Article  Google Scholar 

  8. Lief, F. S., and Henle, W., Virology, 2, 782 (1956).

    Article  Google Scholar 

  9. Duesberg, P. H., Proc. US Nat. Acad. Sci., 59, 930 (1968).

    Article  ADS  CAS  Google Scholar 

  10. Mims, C. A., Brit. J. Exp. Pathol., 37, 129 (1956).

    CAS  Google Scholar 

  11. Bellett, A. J. D., and Cooper, P. D., J. Gen. Microbiol., 21, 498 (1959).

    Article  CAS  Google Scholar 

  12. Rott, R., and Scholtissek, C., J. Gen. Microbiol., 33, 303 (1963).

    Article  CAS  Google Scholar 

  13. Uchida, S., Watanabe, S., and Kato, M., Virology, 28, 135 (1966).

    Article  CAS  Google Scholar 

  14. Blackstein, M. E., Stanners, C. P., and Farmilo, A. J., J. Mol. Biol., 42, 301 (1969).

    Article  CAS  Google Scholar 

  15. Lehmann-Grube, F., Slenczka, W., and Tees, R., J. Gen. Virol., 5, 63 (1969).

    Article  CAS  Google Scholar 

  16. Kingsbury, D. W., Portner, A., and Darlington, R. W. (in the press).

  17. Hackett, A. J., Virology, 24, 51 (1964).

    Article  CAS  Google Scholar 

  18. Huang, A. S., Greenawalt, J. W., and Wagner, R. R., Virology, 30, 161 (1966).

    Article  CAS  Google Scholar 

  19. Huang, A. S., and Wagner, R. R., Virology, 30, 173 (1966).

    Article  CAS  Google Scholar 

  20. Huang, A. S., and Wagner, R. R., J. Mol. Biol., 22, 381 (1966).

    Article  CAS  Google Scholar 

  21. Brown, F., Martin, S. J., Cartwright, B., and Crick, J., J. Gen. Virol., 1, 479 (1967).

    Article  CAS  Google Scholar 

  22. Hackett, A. J., Schaffer, F. L., and Madin, S. H., Virology, 31, 114 (1967).

    Article  CAS  Google Scholar 

  23. Choppin, P. W., Virology, 39, 130 (1969).

    Article  CAS  Google Scholar 

  24. Henle, W., and Henle, G., Amer. J. Med. Sci., 207, 705 (1949).

    Article  Google Scholar 

  25. Traub, E., J. Exp. Med., 69, 801 (1939).

    Article  CAS  Google Scholar 

  26. Mims, C. A., J. Pathol. Bact., 91, 395 (1966).

    Article  CAS  Google Scholar 

  27. Wagner, R. R., and Snyder, R. M., Nature, 196, 393 (1962).

    Article  ADS  CAS  Google Scholar 

  28. Rustigian, R., Virology, 16, 101 (1962).

    Article  CAS  Google Scholar 

  29. Nakai, T., Shand, F. L., and Howatson, A. F., Virology, 38, 50 (1969).

    Article  CAS  Google Scholar 

  30. Raine, C. S., Feldman, L. A., Sheppard, R. D., and Bornstein, M. B., J. Virol., 4, 169 (1969).

    Article  CAS  Google Scholar 

  31. Horta-Barbosa, L., Fuccillo, D. A., Sever, J. L., and Zeman, W., Nature, 221, 974 (1969).

    Article  ADS  CAS  Google Scholar 

  32. Chen, T. T., Watanabe, I., Zeman, W., and Mealy, J., Science, 163, 1193 (1969).

    Article  ADS  CAS  Google Scholar 

  33. Katz, M., Ozanagi, S., and Koprowski, H., Nature, 222, 888 (1969).

    Article  ADS  CAS  Google Scholar 

  34. Huang, A. S., and Wagner, R. R., Proc. US Nat. Acad. Sci., 54, 1579 (1965).

    Article  ADS  CAS  Google Scholar 

  35. Uchida, S., Yoshiike, K., Watanabe, S., and Furuno, A., Virology, 34, 1 (1968).

    Article  CAS  Google Scholar 

  36. Stampfer, M., Baltimore, D., and Huang, A. S., J. Virol., 4, 154 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Wagner, R. R., Levy, A. H., Snyder, R. M., Ratcliff, G. A., and Hyatt, D. F., J. Immunol., 91, 112 (1963).

    CAS  PubMed  Google Scholar 

  38. Sigurdsson, B., J. Exp. Med., 78, 17 (1943).

    Article  CAS  Google Scholar 

  39. Yoshiike, K., Virology, 34, 391 (1968).

    Article  CAS  Google Scholar 

  40. Crick, J., Cartwright, B., and Brown, F., Arch. Ges. Virusforsch., 27, 221 (1969).

    Article  CAS  Google Scholar 

  41. Mills, D. R., Peterson, R. L., and Spiegelman, S., Proc. US Nat. Acad. Sci., 58, 217 (1967).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

HUANG, A., BALTIMORE, D. Defective Viral Particles and Viral Disease Processes. Nature 226, 325–327 (1970). https://doi.org/10.1038/226325a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/226325a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing