Abstract
FEMALES heterozygous for the X-linked glucose-6-phosphate dehydrogenase (G6PD) locus have two populations of cells, each expressing a single phenotype corresponding to one or the other of the two alleles1–3. Where subjects are heterozygous for the A and B electrophoretic variants of G6PD4, one cell population will show only the A electrophoretic variant and the other only the B. The study of these variants has been used to throw light on the origin of certain tumours. Thus, uterine leiomyomas from Negro females heterozygous for G6PD variants A and B are of only one phenotype, although the adjacent uninvolved tissue shows both phenotypes5, which is consistent with a clonal or unicellular origin for this tumour. Similarly, chronic granulocytic leukaemia6 is probably of clonal origin, like the metastatic lesions from one patient with chronic lymphocytic leukaemia7. On the other hand, studies of metastatic lesions from a colonic malignancy7 and epider-moid carcinomas of the cervix have revealed8 the presence of both G6PD phenotypes, which implies a multiclonal origin.
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MURRAY, R., HOBBS, J. & PAYNE, B. Possible Clonal Origin of Common Warts (Verruca vulgaris). Nature 232, 51–52 (1971). https://doi.org/10.1038/232051a0
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DOI: https://doi.org/10.1038/232051a0
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