Abstract
Sodium channels in nerve membranes are postulated to be surrounded by lipid molecules in the gel (or crystalline) phase. Addition of local anaesthetics triggers a change in the surrounding lipids to the fluid, liquid crystalline phase, allowing the sodium channel to close with resulting local anaesthesia. The experimental evidence for this model is discussed.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Levinson, S. R., and Meves, H., Phil. Trans. R. Soc., B 270, 349–352 (1975).
Hille, B., J. gen. Physiol., 59, 637–658 (1972).
Hille, B., J. gen. Physiol., 66, 535–560 (1975).
Ritchie, J. M., Br. J. Anaesth., 47, 191–198 (1975).
Keynes, R. D., and Rojas, E., J. Physiol., Lond., 239, 393–434 (1974).
Staiman, A. L., and Seeman, P., Can. J. Physiol. Pharmac., 53, 513–524 (1975).
Weidling, S., and Tegner, C., in Progress in Medicinal Chemistry, 3 (edit. by Ellis, G. P., and West, G. B.), 332–398 (Butterworths, London, 1963).
Deguchi, T., Jap. J. Pharmac., 17, 267–278 (1967).
Seeman, P., Pharmac. Rev., 24, 583–655 (1972).
Seeman, P., Experientia, 30, 759–760 (1974).
Spyropoulos, C. S., J. gen. Physiol., 40, 849–856 (1957).
Boggs, J. M., Roth, S. M., Young, T., Wong, E., and Hsia, J. C., Molec. Pharmac., 12, 136–143 (1976).
Lee, A. G., Prog. Biophys. molec. Biol., 29, 3–56 (1975).
Lee, A. G., Birdsall, N. J. M., Metcalfe, J. C., Warren, G. B., and Roberts, G. C. K., Proc. R. Soc., B 193, 253–274 (1976).
Levine, Y. K., et al., J. chem. Phys., 60, 2890–2899 (1974).
Boggs, J. M., Young, T., and Hsia, J. C., Molec. Pharmac., 12, 127–135 (1976).
Blaustein, M. P., and Goldman, D. E., J. gen. Physiol., 49, 1043–1063 (1966).
Ray, A., Reynolds, J. A., Polet, H., and Steinhardt, J., Biochemistry, 5, 2606–2616 (1966).
Jost, P. C., Griffiths, O. H., Capaldi, R. A., and Vanderkoi, G., Proc. natn. Acad. Sci. U.S.A., 70, 480–484 (1973).
Hong, K., and Hubbell, W. L., Proc. natn. Acad. Sci. U.S.A., 69, 2617–2621 (1972).
Robinson, J. D., Birdsall, N. J. M., Lee, A. G., and Metcalfe, J. C., Biochemistry, 11, 2903–2909 (1972).
Warren, G. B., Houslay, M. D., Metcalfe, J. C., and Birdsall, N. J. M., Nature, 255, 684–687 (1975).
Warren, G. B., Toon, P. A., Birdsall, N. J. M., Lee, A. G., and Metcalfe, J. C., Proc. natn. Acad. Sci. U.S.A., 71, 622–626 (1974).
Keynes, R. D., Nature, 239, 29–32 (1972).
Blaurock, A. E., and Stoeckenius, W., Nature new Biol., 233, 152–156 (1971).
Stier, A., and Sackmann, E., Biochim. biophys. Acta, 311, 400–408 (1973).
Hill, M. W., Biochim. biophys. Acta, 356, 117–124 (1974).
Lee, A. G., Biochemistry (in the press).
Brink, F., and Posternak, J. M., J. cell. comp. Physiol., 32, 211–233 (1948).
Papahadjopoulos, D., Jacobson, K., Poste, G., and Shepherd, G., Biochim. biophys. Acta, 394, 504–519 (1975).
Lee, A. G., Biochim. biophys. Acta (in the press).
Jacobson, K., and Papahadjopoulos, D., Biochemistry, 14, 152–161 (1975).
Ito, T., Ohnishi, S-i, Ishinago, M., and Kito, M., Biochemistry, 14, 3064–3069 (1975).
Hille, B., Woodhull, A. M., and Shapiro, B. I., Phil. Trans. R. Soc., B 270, 301–318 (1975).
Baker, P. F., Prog. Biophys. molec. Biol., 24, 177–223 (1972).
Brinley, F. J., and Scarpa, A., FEES Lett., 50, 82–85 (1975).
Frazier, D. T., Murayama, K., Abbott, N. J., and Narahashi, T., Eur. J. Pharmac., 32, 102–107 (1975).
Connor, P., Mangat, B. S., and Rao, L. S., J. Pharm. Pharmac., 26, 120P (1974).
Lee, A. G., Birdsall, N. J. M., Metcalfe, J. C., Toon, P. A., and Warren, G. B., Biochemistry, 13, 3699–3705 (1974).
Moore, J. W., Fedn Proc., 17, 113 (1958).
Schoepfle, G. M., and Erlanger, J., Am. J. Physiol., 134, 694–704 (1941).
Schummer, U., Hegner, D., Schnepel, G. H., and Wellhoner, H. H., Biochim. biophys. Acta, 394, 93–101 (1975).
Davis, F. A., and Jacobson, S., J. Neurol. Neurosurg. Psychiat., 34, 551–561 (1971).
Hodgkin, A. L., and Katz, B., J. Physiol., Lond., 109, 240–249 (1949).
Inoue, I., Kobatake, Y., and Tasaki, I., Biochim. biophys. Acta, 307, 471–477 (1973).
Trudell, J. R., Payan, D. G., Chin, J. H., and Cohen, E. N., Biochim. biophys. Acta, 373, 141–144 (1974).
Moore, J. W., Ulbricht, W., and Takata, M., J. gen. Physiol., 48, 279–295 (1964).
Wu, C. H., and Narahashi, T., J. pharm. Pharmac., 184, 155–162 (1973).
Schauf, C. L., Davis, F. A., and Kesler, R. L., J. pharm. Pharmac., 193, 669–675 (1975).
Condouris, G. A., J. pharm. Pharmac., 131, 243–249 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lee, A. Model for action of local anaesthetics. Nature 262, 545–548 (1976). https://doi.org/10.1038/262545a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/262545a0
This article is cited by
-
Blocking ion channels induced by antifungal lipopeptide syringomycin E with amide-linked local anesthetics
Scientific Reports (2018)
-
Marked inhibition of Na+, K+ - ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease
Journal of Bioenergetics and Biomembranes (2013)
-
Long-chain 3-hydroxy fatty acids accumulating in long-chain 3-hydroxyacyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies uncouple oxidative phosphorylation in heart mitochondria
Journal of Bioenergetics and Biomembranes (2013)
-
Neurochemical Evidence that Pristanic Acid Impairs Energy Production and Inhibits Synaptic Na+, K+-ATPase Activity in Brain of Young Rats
Neurochemical Research (2011)
-
The effect of bupivacaine·HCl on the physical properties of neuronal membranes
Protoplasma (2008)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
