Abstract
VASCULAR walls generate from prostaglandin endoperoxides or arachidonic acid an anti-aggregatory and a vasodilator substance, prostacyclin (PGI2)1,2. Several prostaglandins are rapidly inactivated as they traverse the pulmonary circulation3 but prostacyclin passes through unchanged4,5. We report here that prostacyclin is continuously generated by the lungs in vivo or in vitro. Clearly, such an endocrine-like function of the lungs could play an important part in the natural resistance of the organism against intra-arterial thrombosis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Moncada, S., Gryglewski, R., Bunting, S. & Vane, J. R. Nature 263, 663–665 (1976).
Gryglewski, R. J., Bunting, S., Moncada, S., Flower, R. J. & Vane, J. R. Prostaglandins 12, 685–713 (1976).
Ferreira, S. H. & Vane, J. R. Nature 216, 868–873 (1967).
Armstrong, J. M., Lattimer, N., Moncada, S. & Vane, J. R. Br. J. Pharmac 62, 125–130 (1978).
Dusting, G. J., Moncada, S. & Vane, J. R. Proc. Br. pharmac. Soc. 69P–70P (1978).
Gryglewski, R. J., Korbut, R., Ocetkiewicz, A. & Stachwa, T. Naunyn-Schmiedebergs Archs Pharmac. 302, 25–30 (1978).
Johnson, R. A. et al. J. Am. chem. Soc. 99, 12–19 (1977).
Whittaker, N. Tetrahedron Lett. 32, 2805–2808 (1977).
Piper, P. J. & Vane, J. R. Nature 223, 29–35 (1969).
Dusting, G. J., Moncada, S. & Vane, J. R. Prostaglandins 13, 3–15 (1977).
Gryglewski, R. J., Dembinska-Kiec, A., Grodzinska, L. & Panczenko, B. in Lung Cells in Disease (ed. Bouhuys, A.) 289–307 (North-Holland, Amsterdam, 1976).
Vane, J. R. Br. J. Pharmac. 35, 209–242 (1969).
Vane, J. R. in Pharmacology and Pharmacokinetics (eds Teorell, T., Dedrick, R. L. & Condliffe, P. G.) 195–207 (Plenum, New York, 1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GRYGLEWSKI, R., KORBUT, R. & OCETKIEWICZ, A. Generation of prostacyclin by lungs in vivo and its release into the arterial circulation. Nature 273, 765–767 (1978). https://doi.org/10.1038/273765a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/273765a0
This article is cited by
-
Altered prostanoid metabolism contributes to impaired angiogenesis in persistent pulmonary hypertension in a fetal lamb model
Pediatric Research (2015)
-
Adventures and Excursions in Bioassay: The Stepping Stones to Prostacylin
Bioscience Reports (2004)
-
Systemische Freisetzung von Prostanoiden nach chirurgisch induzierter Verletzung des Lungengewebes
Langenbecks Archiv für Chirurgie (1997)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
