Abstract
Genetic, molecular and cellular analyses of the HLA-D region of the major histocompatability complex (MHC) in man have led to the definition of three different products. Two of these, DR and MB (the latter also known as DC (ref. 1) and LB-E (ref. 2)) are defined with serological reagents; the third, known as SB (ref. 3) and PL-3 (ref. 4) is defined with primed lymphocyte typing (PLT) cells5. The classical features attributed to HLA-D region encoded (class II) molecules are that they are cell-surface dimers consisting of a structurally conserved α-chain noncovalently associated with a polymorphic β-chain and that they are found primarily on B lymphocytes, some monocyte populations, endothelial and certain other cells6. Using these criteria a monoclonal antibody,. B7/21, was described as reactive with HLA-DR (ref. 7). We have now re-evaluated B7/21 antibody reactivity using mutant lymphoblastoid cell lines. It appears that this antibody does not react with the molecularly defined D region products described to date but instead, recognizes a class II antigen with distinctive molecular characteristics. We provisionally refer to this antigen as FA.
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References
Tanigaki, N., Tosi, R., Pressman, D. & Ferrara, G. B. Immunogenetics 10, 151–167 (1980).
Van Leeuwen, A. et al. Histocompatibility Testing (ed. Terasaki, P. F.) 853 (University of Los Angeles, 1980).
Shaw, S., Pollack, M. S., Payne, S. M. & Johnson, A. H. Hum. Immun. 1, 177–185 (1980).
Termijtelen, A., Bradley, B. A. & van Rood, J. J. Tissue Antigens 15, 267–274 (1980).
Sheehey, M. J., Sondel, P. M., Bach, M. L., Wank, R. & Bach, F. H. Science 188, 1308–1310 (1975).
Strominger, J. L. et al. in The Role of the Major Histocompatibility Complex in Immunology (ed. Dorf, M. E.) 115–172 (Garland, New York, 1981).
Royston, I., Omary, M. B. & Trowbridge, I. S. Transplant Proc. 13, 761–766 (1981).
Kavathas, P., Bach, F. H. & DeMars, R. Proc. natn. Acad. Sci. U.S.A. 77, 4251–4255 (1980).
Kavathas, P., DeMars, R. & Bach, F. H. Hum. Immun. 4, 317–324 (1980).
Kavathas, P., DeMars, R., Bach, F. H. & Shaw, S. Nature 293, 747–749 (1981).
DeMars, R., Chang, C. C. & Rudersdorf, R. R. Hum. Immun. (in the press).
Shaw, S., Kavathas, P., Pollack, M. S., Charmot, D. & Mawas, C. Nature 293, 745–746 (1982).
Bach, F. H., Reinsmoen, N. L. & Segall, M. Transplantn Proc. 15, 102–108 (1983).
Shaw, S. et al. J. exp. Med. 156, 731–743 (1982).
DeMars, R. et al. J. Immun. (in the press).
Auffray, C., Kuo, J., DeMars, R. & Strominger, J. L. Nature 304, 174–177 (1983).
Lampson, L. A. & Levy, R. J. Immun. 125, 293–299 (1980).
Shackelford, D. A., Mann, D., van Rood, J. J., Ferrara, G. B. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 78, 4566–4570 (1981).
Shackelford, D. A., Kaufman, J. F., Korman, A. J. & Strominger, J. L. Immun. Rev. 66, 133–187 (1982).
Shackelford, D. A., Lampson, L. A. & Strominger, J. L. J. Immun. 127, 1403–1410 (1981).
deKretser, T. A., Crumpton, M. J., Bodmer, J. G. & Bodmer, W. F. Eur. J. Immun. 12, 214–221 (1982).
Brodsky, F. M., Parham, P. & Bodmer, W. F. Tissue Antigens 16, 30–48 (1980).
Orr, H. T. et al. Nature 293, 454–455 (1982).
Orr, H. T. & DeMars, R. Nature 302, 534–536 (1983).
Nadler, L. M. et al. Nature 290, 591–593 (1981).
Hurley, C. H., Shaw, S., Nadler, L., Schlossman, S. & Capra, J. B. J. exp. Med. 156, 1557–1562 (1982).
Ledbetter, J., Nowinski, R. C. & Emery, S. J. Virol. 22, 65–73 (1977).
Watson, A., Dunlap, B. & Bach, F. H. J. Immun. 127, 38–42 (1981).
Laemmli, U. K. Nature 227, 680–685 (1970).
Bonner, W. M. & Laskey, R. A. Eur. J. Immun. 46, 83–87 (1974).
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Watson, A., DeMars, R., Trowbridge, I. et al. Detection of a novel human class II HLA antigen. Nature 304, 358–361 (1983). https://doi.org/10.1038/304358a0
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DOI: https://doi.org/10.1038/304358a0
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