Abstract
The complete (172,282 base pairs) nucleotide sequence of the B95-8 strain of Epstein–Barr virus has been established using the dideoxynucleotide/M13 sequencing procedure. Many RNA polymerase II promoters have been mapped and the mRNAs from these promoters have been assigned to the latent or early/late productive virus cycles. Likely protein-coding regions have been identified and three of these have been shown to encode a ribonucleotide reductase, a DNA polymerase and two surface glycoproteins.
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References
Epstein, M. A., Achong, B. G. & Barr, Y. M. Lancet i, 702–703 (1964).
Roizman, B. (ed.) The Herpesviruses, The Viruses Vol. 1 (Plenum, New York, 1982).
Epstein, M. A. & Achong, B. G. (eds) The Epstein–Barr Virus (Springer, Berlin, 1979).
Henle, W., Diehl, V., Kohn, G., zur Hausen, H. & Henle, G. Science 157, 1064–1065 (1967).
Pope, J. H., Horne, M. K. & Scott, W. Int. J. Cancer 3, 857–866 (1968).
Jondal, M. & Klein, G. J. exp. Med. 138, 1365–1378 (1973).
Morgan, D. G., Niederman, J. C., Miller, G., Smith, H. W. & Dowaliby, J. M. Lancei ii, 1154–1157 (1979).
Lemon, S. M., Hutt, L. M., Shaw, J. E., Li, J. L. H. & Pagano, J. S. Nature 268, 268–270 (1977).
Miller, G., Shope, T., Lisco, H., Stitt, D. & Lipman, M. Proc. natn. Acad. Sci. U.S.A. 69, 383–387 (1972).
zur Hausen, H., Hecker, E., O'Neill, F. J. & Freese, U. K. Nature 272, 373–375 (1978).
Pritchett, R. F., Hayward, S. D. & Kieff, E. J. Virol. 15, 556–569 (1975).
Hayward, S. D. & Kieff, E. J Virol. 23, 421–429 (1977).
Lindahl, T. et al. J. molec. Biol. 102, 511–530 (1976).
Dambaugh, T. et al. Proc. natn. Acad. Sci. U.S.A. 77, 2999–3003 (1980).
Given, D., Yee, D., Griem, K. & Kieff, E. J. Virol. 30, 852–862 (1979).
Kintner, C. R. & Sugden, B. Cell 17, 661–671 (1979).
Given, D. & Kieff, E. J. Virol. 31, 315–324 (1979).
Rymo, L. & Forsblom, S. Nucleic Acids Res. 5, 1387–1402 (1978).
Hayward, S. D., Nogee, L. & Hayward, G. S. J. Virol. 33, 507–521 (1980).
Skare, J. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 77, 3860–3864, 7510 (1980).
Arrand, J. R. et al. Nucleic Acids Res. 9, 2999–3014 (1981).
Hummel, M. & Kieff, E. J. Virol. 43, 262–272 (1982).
Weigel, R. & Miller, G. Virology 125, 287–298 (1983).
Hummel, M. & Kieff, E. Proc. natn. Acad. Sci. U.S.A. 79, 5698–5702 (1982).
Seibl, R. & Wolf, H. Virology (submitted).
Cohen, L. K., Spech, S. H., Roberts, B. E. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. (in the press).
Deininger, P. Analyt. Biochem. 129, 216–223 (1983).
Messing, J. & Vieira, J. Gene 19, 269–276 (1982).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Staden, R. Nucleic Acids Res. 10, 4731–4751 (1982); 12, 499–503 (1984).
Bankier, A. T. & Barrell, B. G. Techniques in the Life Sciences Vol. B5 (Elsevier, Ireland, 1983).
Bankier, A. T. et al. Molec. Biol. Med. 1, 425–445 (1983).
Bankier, A. T., Deininger, P. L., Farrell, P. J. & Barrell, B. G. Molec. Biol. Med. 1, 21–45 (1983).
Seguin, C. S., Farrell, P. J. & Barrell, B. G. Molec. Biol. Med. 1, 369–392 (1983).
Biggin, M., Farrell, P. J. & Barrell, B. G. EMBO J. 3, 1083–1090 (1984).
Gibson, T., Stockwell, P., Ginsberg, M. & Barrell, B. G. Nucleic Acids Res. (in the press).
Farrell, P. J., Deininger, P. L., Bankier, A. T. & Barrell, B. G. Proc. natn. Acad. Sci. U.S.A. 80, 1565–1569 (1983).
Farrell, P. J., Bankier, A., Seguin, C., Deininger, P. & Barrell, B. G. EMBO J. 2, 1331–1338 (1983).
Jeang, K. & Hayward, S. D. J. Virol. 48, 135–148 (1983).
Jones, M., Foster, L., Sheedy, T. & Griffin, B. E. EMBO J. 3, 813–821 (1984).
Hayward, S. D., Lazarowitz, S. G. & Hayward, G. S. J. Virol. 43, 201–212 (1982).
Jones, M. D. & Griffin, B. E. Nucleic Acids Res. 11, 3919–3937 (1983).
Cheung, A. & Kieff, E. J. Virol. 44, 286–294 (1982).
Hennessy, K. & Kieff, E. Proc. natn. Acad. Sci. U.S.A. 80, 5665–5669 (1983).
Staden, R. Nucleic Acids Res. 12, 521–538 (1984).
Raab-Traub, N., Pritchett, R. & Kieff, E. J. Virol. 27, 388–398 (1978).
Delius, H. & Bornkamm, G. W. J. Virol. 27, 81–89 (1978).
Arrand, J. R. & Rymo, L. J. Virol. 41, 376–379 (1982).
Rosa, M. D., Gottlieb, E., Lerner, M. R. & Steitz, J. A. Molec. cell. Biol. 1, 785–796 (1981).
Bhat, R. A. & Thimmappaya, B. Proc. natn. Acad. Sci. U.S.A. 80, 4789–4793 (1983).
Yates, J., Warren, N., Reisman, D. & Sugden, B. Proc. natn. Acad. Sci. U.S.A. (in the press).
Manley, J. L., Fire, A., Cano, A., Sharp, P. A. & Gefter, M. Proc. natn. Acad. Sci. U.S.A. 77, 3855–3859 (1980).
Corden, J. et al. Science 209, 1406–1414 (1980).
Summers, W. C. & Klein, G. J. Virol. 18, 151–155 (1976).
Herz, C. & Roizman, B. Cell 33, 145–151 (1983).
Kieff, E. et al. J. infect. Dis. 146, 506–517 (1982).
Rymo, L. J. Virol. 32, 8–18 (1979).
Van Santen, V., Cheung, A., Hummel, M. & Kieff, E. J. Virol. 46, 424–433 (1983).
Heller, M., van Santen, V. & Kieff, E. J. Virol. 44, 311–320 (1982).
Fischer, D. K. et al. Proc. natn. Acad. Sci. U.S.A. 81, 43–47 (1984).
Hennessy, K., Heller, M., van Santen, V. & Kieff, E. Science 220, 1396–1398 (1983).
Grogan, E. A. et al. Proc. natn. Acad. Sci. U.S.A. 80, 7650–7653 (1983).
Swain, M. A. & Galloway, D. A. J. Virol. 46, 1045–1050 (1983).
Walker, J. E., Saraste, M., Runswick, M. J. & Gay, N. J. EMBO J. 1, 945–951 (1982).
Hofmann, G. J., Lazarowitz, S. G. & Hayward, S. D. Proc. natn. Acad. Sci. U.S.A. 77, 2979–2983 (1980).
Thorley-Lawson, D. A. & Poodry, C. A. J. Virol. 43, 730–736 (1982).
Hummel, M., Thorley-Lawson, D. A. & Kieff, E. J. Virol. 49, 413–417 (1984).
Klein, G. Cell 32, 311–315 (1983).
Griffin, B. E. & Karran, L. Nature 309, 78–82 (1984).
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Baer, R., Bankier, A., Biggin, M. et al. DNA sequence and expression of the B95-8 Epstein—Barr virus genome. Nature 310, 207–211 (1984). https://doi.org/10.1038/310207a0
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DOI: https://doi.org/10.1038/310207a0
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