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Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line

Nature volume 314, pages 330–334 (1985)Cite this article

Abstract

Two genes that code for a hapten-specific immunoglobulin M (IgM) have been introduced into the mouse germ line. The transgenic antibody represents 10–50% of the serum IgM and is expressed on the membrane of B cells. B-cell hybridoma lines show that a negative feedback inhibition of μ and κ transgenic products on the immunoglobulin heavy-chain rearrangement is possible.

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Author notes

  1. Sandro Rusconi

    Present address: School of Medicine, Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94143, USA

  2. Georges Köhler

    Present address: Max-Planck Institut für Immunobiologie, Stübeweg 51, Postfach 1169, D-7800, Freiburg, FRG

Authors and Affiliations

  1. Institut für Molekularbiologie II der Universität Zürich, Hönggerberg, CH-8093, Zürich, Switzerland

    Sandro Rusconi

  2. Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005, Basel, Switzerland

    Georges Köhler

Authors
  1. Sandro Rusconi
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  2. Georges Köhler
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Rusconi, S., Köhler, G. Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line. Nature 314, 330–334 (1985). https://doi.org/10.1038/314330a0

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