Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

cAMP takes control

Nature Cell Biology volume 2, pages E167–E168 (2000)Cite this article

Although it has long been appreciated that cAMP-related signalling can control cell growth, the mechanism by which this control is exerted has remained unknown. However, new findings now show how cAMP, acting through protein kinase A (PKA), maintains cells in an anchorage-dependent state by inhibiting mitogen-activated protein kinase (MAPK) signalling through p21-activated kinases (PAKs).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Inhibition of cell-cycle progression and survival by PKA in the absence of cell–matrix adhesion.

References

  1. Aplin, A. E., Howe, A. K. & Juliano, R. Curr. Opin. Cell Biol. 11, 737 –744 (1999).

    Article  CAS  Google Scholar 

  2. Frisch, S. & Ruoslahti, E. Curr. Opin. Cell Biol. 9, 701–706 (1997).

    Article  CAS  Google Scholar 

  3. del Pozo, M., Price, L., Alderson, N., Ren, X. & Schwartz, M. EMBO J. 19, 2008– 2014 (2000).

    Article  CAS  Google Scholar 

  4. Bagrodia, S. & Cerione, R. A. Trends Cell Biol. 9, 350–355 (1999).

    Article  CAS  Google Scholar 

  5. Assoian, R. K., J. Cell Biol. 136, 1–4 ( 1997).

    Article  CAS  Google Scholar 

  6. Daniels, R. H. & Bokoch, G. M. Trends Biochem. Sci. 24, 350–353 (1999).

    Article  CAS  Google Scholar 

  7. Schoenwaelder, S. M. & Burridge, K. Curr. Opin. Cell Biol. 11, 274–286 ( 1999).

    Article  CAS  Google Scholar 

  8. Schurmann, A. et al. Mol. Cell Biol. 20, 453– 461 (2000).

    Article  CAS  Google Scholar 

  9. Harada, H. et al. Mol. Cell 3, 413–422 (1999).

    Article  CAS  Google Scholar 

  10. Dransfield, D. et al. EMBO J. 16, 35–43 (1997).

    Article  CAS  Google Scholar 

  11. Yu, Q., Toole, B. & Stamenkovic, I. J. Exp. Med. 186, 1985– 1996 (1997).

    Article  CAS  Google Scholar 

  12. Lamb, R. et al. Nature Cell Biol. 2, 281– 287 (2000).

    Article  CAS  Google Scholar 

  13. Zondag, G. et al. J. Cell Biol. 149, 775– 781 (2000).

    Article  CAS  Google Scholar 

  14. Nauert, J., Klauck, T., Langeborg, L. & Scott, J. Curr. Biol. 7, 52–62 ( 1997).

    Article  CAS  Google Scholar 

  15. Lin, X., Nelson, P. & Gelman, I. Mol Cell Biol. (in the press).

  16. Sieg, D. et al. Nature Cell Biol. 2, 249– 256 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Burnham Institute, 10901 North Torrey Pines Road, La Jolla, 92037, California , USA

    Steven M. Frisch

Authors
  1. Steven M. Frisch
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Frisch, S. cAMP takes control. Nat Cell Biol 2, E167–E168 (2000). https://doi.org/10.1038/35023650

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35023650

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing