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Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents

Nature volume 355, pages 50–55 (1992)Cite this article

Abstract

Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.

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Author notes

  1. Roger A. Nicoll: To whom correspondence should be addressed.

Authors and Affiliations

  1. Departments of Pharmacology and Physiology, University of California, San Francisco, California, 94143-0450, USA

    Toshiya Manabe, Pius Renner & Roger A. Nicoll

Authors
  1. Toshiya Manabe
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  2. Pius Renner
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  3. Roger A. Nicoll
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Manabe, T., Renner, P. & Nicoll, R. Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents. Nature 355, 50–55 (1992). https://doi.org/10.1038/355050a0

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