Abstract
MEGAKARYOCYTOPOIESIS is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocyte progenitors1,2, and the second, thrombopoietin, is a megakaryocyte maturation factor3. Neither of these factors has been fully characterized. The proto-oncogene c-mpl, an orphan member of the haematopoietin receptor family4–6, is specifically involved in megakaryocyte regulation7. Here we present evidence that the c-mpl-encoded receptor binds a ligand (c-Mpl ligand) which is a humoral factor implicated in platelet homeostasis. Our results suggest that c-Mpl ligand, thrombopoietin and MK-CSF might be the same molecule.
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Wendling, F., Maraskovsky, E., Debili, N. et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369, 571–574 (1994). https://doi.org/10.1038/369571a0
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DOI: https://doi.org/10.1038/369571a0
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