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Ion channels

Opposite thermosensor in fruitfly and mouse

Abstract

Several members of the TRP (for transient receptor potential) family of ion channels act as physiological temperature sensors in mammals1,2,3,4,5,6, but it is not known whether the invertebrate TRP subfamilies that are found in the fruitfly Drosophila and the roundworm Caenorhabditis elegans can be directly activated by temperature. Here we show that the Drosophila orthologue of ANKTM1, which is a cold-activated ion channel in mammals, responds to a warming rather than a cooling stimulus. The thermosensing function of these channels is therefore evolutionarily conserved, and they show a surprising flexibility in their response to different temperature ranges.

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Figure 1: Drosophila orthologue of the mammalian ion channel ANKTM1 is activated by warm, not cold, temperatures.

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References

  1. Caterina, M. J. & Julius, D. Annu. Rev. Neurosci. 24, 487–517 (2001).

    Article  CAS  PubMed  Google Scholar 

  2. Guler, A. D. et al. J. Neurosci. 22, 6408–6414 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Peier, A. M. et al. Science 296, 2046–2049 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. McKemy, D. D., Neuhausser, W. M. & Julius, D. Nature 416, 52–58 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Peier, A. M. et al. Cell 108, 705–715 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Story, G. M. et al. Cell 112, 819–829 (2003).

    Article  CAS  PubMed  Google Scholar 

  7. Sayeed, O. & Benzer, S. Proc. Natl Acad. Sci. USA 93, 6079–6084 (1996).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  8. Liu, L., Yermolaieva, O., Johnson, W. A., Abboud, F. M. & Welsh, M. J. Nature Neurosci. 6, 267–273 (2003).

    Article  CAS  PubMed  Google Scholar 

  9. Tobin, D. et al. Neuron 35, 307–318 (2002).

    Article  CAS  PubMed  Google Scholar 

  10. Tracey, W. D., Wilson, R. I., Laurent, G. & Benzer, S. Cell 113, 261–273 (2003).

    Article  CAS  PubMed  Google Scholar 

  11. Walker, R. G., Willingham, A. T. & Zuker, C. S. Science 287, 2229–2234 (2000).

    Article  ADS  CAS  PubMed  Google Scholar 

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Correspondence to Ardem Patapoutian.

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The authors declare no competing financial interests.

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Viswanath, V., Story, G., Peier, A. et al. Opposite thermosensor in fruitfly and mouse. Nature 423, 822–823 (2003). https://doi.org/10.1038/423822a

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