Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perinatal/Neonatal Case Presentation
  • Published:

Perinatal/Neonatal Case Presentation

Novel H1N1 influenza in neonates: from mild to fatal disease

Journal of Perinatology volume 31, pages 446–448 (2011)Cite this article

Subjects

Abstract

Analysis of pediatric deaths associated with pandemic A H1N1 influenza shows that fatal outcome is more likely in young children, under the age of 5. Neonates, because of the immaturity of their immune system, could represent a high-risk group for severe disease and fatal outcome. We present a group of five neonates with confirmed novel influenza A H1N1 infection. This report indicates that the full spectrum of influenza A H1N1 infection ranging from mild febrile illness with spontaneous recovery to severe disease with fatal outcome may be expected even in neonates.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. World Health Organization. http://www.who.int/csr/disease/swineflu/4th_meeting_ihr/en DG Statement following the meeting of the Emergency Committee (accessed 3 March 2010).

  2. Surveillance for pediatric deaths associated with 2009 pandemic influenza A (H1N1) virus infection: United States, April-August 2009. MMWR Morb Mortal Wkly Rep 2009; 58: 941–947.

  3. You D, Ripple M, Balakrishna S, Troxclair D, Sandquist D, Ding L et al. Inchoate CD8+ T cell responses in neonatal mice permit influenza-induced persistent pulmonary dysfunction. J Immunol 2008; 181: 3486–3494.

    Article  CAS  Google Scholar 

  4. Wilkinson DJ, Buttery JP, Anderson CC . Infuenza in neonatal intensive care unit. J Perinatol 2006; 26: 772–776.

    Article  CAS  Google Scholar 

  5. Welliver TP, Garofalo RP, Hosakote Y, Hintz KH, Avendano L, Sanchez K et al. Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses. J Infect Dis 2007; 195: 1126–1136.

    Article  CAS  Google Scholar 

  6. Gill JR, Sheng ZM, Ely SF, Guinee DG, Beasley MB, Suh J et al. Pulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections. Arch Pathol Lab Med 2010; 134: 235–243.

    PubMed  PubMed Central  Google Scholar 

  7. Dulyachai W, Makkoch J, Rianthavorn P, Changpinyo M, Prayangprecha S, Payungporn S et al. Perinatal pandemic (H1N1) 2009 infection, Thailand. Emerg Infect Dis 2010; 16: 343–344.

    Article  Google Scholar 

  8. Libster R, Bugna J, Coviello S, Hijano DR, Dunaiewsky M, Reynoso N et al. Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina. N Engl J Med 2010; 362: 45–55.

    Article  CAS  Google Scholar 

  9. Kimberlin DW, Shalabi M, Abzug MJ, Lang D, Jacobs RF, Storch G et al. NIAID Collaborative Antiviral Study Group. Safety of oseltamivir compared with the adamantanes in children less than 12 months of age. Pediatr Infect Dis J 2010; 29: 195–198.

    Article  Google Scholar 

  10. Jain S, Kamimoto L, Bramley AM, Schmitz AM, Benoit SR, Louie J et al. Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N Engl J Med 2009; 361: 1935–1944.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mother and Child Health Care Institut, ‘Dr Vukan Cupic’, Belgrade, Serbia

    J Martic, N Savic, P Minic, S Pasic & B Jankovic

  2. Institute of Virology, Vaccine and Sera ‘Torlak’, Belgrade, Serbia

    J Nedeljkovic

Authors
  1. J Martic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N Savic
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P Minic
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S Pasic
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J Nedeljkovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B Jankovic
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B Jankovic.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Martic, J., Savic, N., Minic, P. et al. Novel H1N1 influenza in neonates: from mild to fatal disease. J Perinatol 31, 446–448 (2011). https://doi.org/10.1038/jp.2010.194

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2010.194

Keywords

Search

Advanced search

Quick links