Pathobiology in FocusCanonical Wnt signaling in systemic sclerosis
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This review comprehensively describes the pivotal role of Wnt/β-catenin in systemic sclerosis. The emerging story of this fibrotic disease which affects not only the skin but the gastrointestinal system, lungs and heart, is the relationship of TGF-b with increased Wnt/β-catenin signaling and the amelioration of fibrosis with Dkk-1. Both translational implications and the limitations of prolonged Wnt/β-catenin inhibition are discussed.
© 2016 United States & Canadian Academy of Pathology.