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SorCS2 is required for BDNF-dependent plasticity in the hippocampus

Molecular Psychiatry volume 21, pages 1740–1751 (2016)Cite this article

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Abstract

SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic studies have suggested SORCS2 to confer risk of bipolar disorder, schizophrenia and attention deficit-hyperactivity disorder. Here we report that hippocampal N-methyl-d-aspartate receptor-dependent synaptic plasticity is eliminated in SorCS2-deficient mice. This defect was traced to the ability of SorCS2 to form complexes with the neurotrophin receptor p75NTR, required for pro-brain-derived neurotrophic factor (BDNF) to induce long-term depression, and with the BDNF receptor tyrosine kinase TrkB to elicit long-term potentiation. Although the interaction with p75NTR was static, SorCS2 bound to TrkB in an activity-dependent manner to facilitate its translocation to postsynaptic densities for synaptic tagging and maintenance of synaptic potentiation. Neurons lacking SorCS2 failed to respond to BDNF by TrkB autophosphorylation, and activation of downstream signaling cascades, impacting neurite outgrowth and spine formation. Accordingly, Sorcs2–/– mice displayed impaired formation of long-term memory, increased risk taking and stimulus seeking behavior, enhanced susceptibility to stress and impaired prepulse inhibition. Our results identify SorCS2 as an indispensable coreceptor for p75NTR and TrkB in hippocampal neurons and suggest SORCS2 as the link between proBDNF/BDNF signaling and mental disorders.

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References

  1. Hartz SM, Pato CN, Medeiros H, Cavazos-Rehg P, Sobell JL, Knowles JA et al. Comorbidity of severe psychotic disorders with measures of substance use. JAMA Psychiatry 2014; 71: 248–254.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Manji HK, Drevets WC, Charney DS . The cellular neurobiology of depression. Nat Med 2001; 7: 541–547.

    Article  CAS  PubMed  Google Scholar 

  3. Schloesser RJ, Martinowich K, Manji HK . Mood-stabilizing drugs: mechanisms of action. Trends Neurosci 2012; 35: 36–46.

    Article  CAS  PubMed  Google Scholar 

  4. Lopez AD, Murray CC . The global burden of disease, 1990–2020. Nat Med 1998; 4: 1241–1243.

    Article  CAS  PubMed  Google Scholar 

  5. Nagappan G, Lu B . Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends Neurosci 2005; 28: 464–471.

    Article  CAS  PubMed  Google Scholar 

  6. Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S et al. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 2004; 306: 487–491.

    Article  CAS  PubMed  Google Scholar 

  7. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA et al. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 2005; 8: 1069–1077.

    Article  CAS  PubMed  Google Scholar 

  8. Redondo RL, Morris RG . Making memories last: the synaptic tagging and capture hypothesis. Nat Rev Neurosci 2011; 12: 17–30.

    Article  CAS  PubMed  Google Scholar 

  9. Meyer-Franke A, Wilkinson GA, Kruttgen A, Hu M, Munro E, Hanson MG Jr et al. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 1998; 21: 681–693.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ji Y, Pang PT, Feng L, Lu B . Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nat Neurosci 2005; 8: 164–172.

    Article  CAS  PubMed  Google Scholar 

  11. Lu Y, Ji Y, Ganesan S, Schloesser R, Martinowich K, Sun M et al. TrkB as a potential synaptic and behavioral tag. J Neurosci 2011; 31: 11762–11771.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Deinhardt K, Kim T, Spellman DS, Mains RE, Eipper BA, Neubert TA et al. Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal 2011; 4: ra82.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Glerup S, Olsen D, Vaegter CB, Gustafsen C, Sjoegaard SS, Hermey G et al. SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron 2014; 82: 1074–1087.

    Article  CAS  PubMed  Google Scholar 

  14. Willnow TE, Petersen CM, Nykjaer A . VPS10P-domain receptors—regulators of neuronal viability and function. Nat Rev Neurosci 2008; 9: 899–909.

    Article  CAS  PubMed  Google Scholar 

  15. Glerup S, Nykjaer A, Vaegter CB . Sortilins in neurotrophic factor signaling. Handb Exp Pharmacol 2014; 220: 165–189.

    Article  CAS  PubMed  Google Scholar 

  16. Nielsen MS, Keat SJ, Hamati JW, Madsen P, Gutzmann JJ, Engelsberg A et al. Different motifs regulate trafficking of SorCS1 isoforms. Traffic 2008; 9: 980–994.

    Article  CAS  PubMed  Google Scholar 

  17. Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D et al. The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J 2001; 20: 2180–2190.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, Kjolby M et al. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci 2011; 14: 54–61.

    Article  CAS  PubMed  Google Scholar 

  19. Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B et al. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry 2008; 13: 197–207.

    Article  CAS  PubMed  Google Scholar 

  20. Ollila HM, Soronen P, Silander K, Palo OM, Kieseppa T, Kaunisto MA et al. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family cohort. Mol Psychiatry 2009; 14: 351–353.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Christoforou A, McGhee KA, Morris SW, Thomson PA, Anderson S, McLean A et al. Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p. Mol Psychiatry 2011; 16: 240–242.

    Article  CAS  PubMed  Google Scholar 

  22. Alemany S, Ribases M, Vilor-Tejedor N, Bustamante M, Sanchez-Mora C, Bosch R et al. New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder. Am J Med Genet B 2015; 168: 459–470.

    Article  CAS  Google Scholar 

  23. Cross-Disorder Group of the Psychiatric Genomics C. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013; 381: 1371–1379.

    Article  Google Scholar 

  24. Cross-Disorder Group of the Psychiatric Genomics C Cross-Disorder Group of the Psychiatric Genomics C Lee SH Cross-Disorder Group of the Psychiatric Genomics C Ripke S Cross-Disorder Group of the Psychiatric Genomics C Neale BM Cross-Disorder Group of the Psychiatric Genomics C Faraone SV Cross-Disorder Group of the Psychiatric Genomics C Purcell SM et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013; 45: 984–994.

    Google Scholar 

  25. Castren E, Rantamaki T . The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity. Dev Neurobiol 2010; 70: 289–297.

    CAS  PubMed  Google Scholar 

  26. Martinowich K, Manji H, Lu B . New insights into BDNF function in depression and anxiety. Nat Neurosci 2007; 10: 1089–1093.

    Article  CAS  PubMed  Google Scholar 

  27. Rybakowski JK . BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. Pharmacogenomics 2008; 9: 1589–1593.

    Article  CAS  PubMed  Google Scholar 

  28. Okada T, Hashimoto R, Numakawa T, Iijima Y, Kosuga A, Tatsumi M et al. A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity. Mol Psychiatry 2006; 11: 695–703.

    Article  CAS  PubMed  Google Scholar 

  29. Hosang GM, Uher R, Keers R, Cohen-Woods S, Craig I, Korszun A et al. Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder. J Affect Disord 2010; 125: 345–349.

    Article  CAS  PubMed  Google Scholar 

  30. Cheah SY, Lawford BR, Young RM, Connor JP, Phillip Morris C, Voisey J . BDNF SNPs are implicated in comorbid alcohol dependence in schizophrenia but not in alcohol-dependent patients without schizophrenia. Alcohol Alcohol 2014; 49: 491–497.

    Article  CAS  PubMed  Google Scholar 

  31. Nees F, Witt SH, Dinu-Biringer R, Lourdusamy A, Tzschoppe J, Vollstadt-Klein S et al. BDNF Val66Met and reward-related brain function in adolescents: role for early alcohol consumption. Alcohol 2015; 49: 103–110.

    CAS  PubMed  Google Scholar 

  32. Moncada D, Viola H . Induction of long-term memory by exposure to novelty requires protein synthesis: evidence for a behavioral tagging. J Neurosci 2007; 27: 7476–7481.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Fadok JP, Dickerson TM, Palmiter RD . Dopamine is necessary for cue-dependent fear conditioning. J Neurosci 2009; 29: 11089–11097.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Lu B, Pang PT, Woo NH . The yin and yang of neurotrophin action. Nat Rev Neurosci 2005; 6: 603–614.

    Article  CAS  PubMed  Google Scholar 

  35. Deinhardt K, Kim T, Spellman DS, Mains RE, Eipper BA, Neubert TA et al. Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal 2011; 4, ra82.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Zhang D, Zhang J, Bian C, Deng Q . Postnatal and ovariectomic regulation of postsynaptic density protein-95 in the hippocampus of female Sprague–Dawley rats. Synapse 2010; 64: 875–878.

    Article  CAS  PubMed  Google Scholar 

  37. Messaoudi E, Ying SW, Kanhema T, Croll SD, Bramham CR . Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. J Neurosci 2002; 22: 7453–7461.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen SH et al. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 2004; 306: 487–491.

    Article  CAS  PubMed  Google Scholar 

  39. Suzuki S, Numakawa T, Shimazu K, Koshimizu H, Hara T, Hatanaka H et al. BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. J Cell Biol 2004; 167: 1205–1215.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Frey U, Morris RGM . Synaptic tagging and long-term potentiation. Nature 1997; 385: 533–536.

    Article  CAS  PubMed  Google Scholar 

  41. Lu Y, Ji YY, Ganesan S, Schloesser R, Martinowich K, Sun M et al. TrkB as a potential synaptic and behavioral tag. J Neurosci 2011; 31: 11762–11771.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Wang SH, Redondo RL, Morris RGM . Relevance of synaptic tagging and capture to the persistence of long-term potentiation and everyday spatial memory. Proc Natl Acad Sci USA 2010; 107: 19537–19542.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Minichiello L, Korte M, Wolfer D, Kuhn R, Unsicker K, Cestari V et al. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 1999; 24: 401–414.

    Article  CAS  PubMed  Google Scholar 

  44. Linnarsson S, Bjorklund A, Ernfors P . Learning deficit in BDNF mutant mice. Eur J Neurosci 1997; 9: 2581–2587.

    Article  CAS  PubMed  Google Scholar 

  45. Kurnianingsih YA, Kuswanto CN, McIntyre RS, Qiu A, Ho BC, Sim K . Neurocognitive-genetic and neuroimaging–genetic research paradigms in schizophrenia and bipolar disorder. J Neural Transm 2011; 118: 1621–1639.

    Article  CAS  PubMed  Google Scholar 

  46. Perry W, Minassian A, Feifel D, Braff DL . Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania. Biol Psychiatry 2001; 50: 418–424.

    Article  CAS  PubMed  Google Scholar 

  47. Braff DL, Grillon C, Geyer MA . Gating and habituation of the startle reflex in schizophrenic patients. Archiv Gen Psychiatry 1992; 49: 206–215.

    Article  CAS  Google Scholar 

  48. Takata A, Kawasaki H, Iwayama Y, Yamada K, Gotoh L, Mitsuyasu H et al. Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case–control samples. Psychiatry Clin Neurosci 2011; 65: 280–285.

    Article  CAS  PubMed  Google Scholar 

  49. Fabbri C, Serretti A . Genetics of long-term treatment outcome in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 2016; 65: 17–24.

    Article  CAS  PubMed  Google Scholar 

  50. Martinowich K, Schloesser RJ, Manji HK . Bipolar disorder: from genes to behavior pathways. J Clin Invest 2009; 119: 726–736.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT . Neurobiology of schizophrenia. Neuron 2006; 52: 139–153.

    CAS  PubMed  Google Scholar 

  52. Wen Z, Nguyen HN, Guo Z, Lalli MA, Wang X, Su Y et al. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature 2014; 515: 414–418.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014; 511: 421–427.

    Article  Google Scholar 

  54. Nagappan G, Zaitsev E, Senatorov VV Jr, Yang J, Hempstead BL, Lu B . Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proc Natl Acad Sci USA 2009; 106: 1267–1272.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Martin KC, Kosik KS . Synaptic tagging—who's it? Nat Rev Neurosci 2002; 3: 813–820.

    Article  CAS  PubMed  Google Scholar 

  56. Kelleher RJ, Govindarajan A, Tonegawa S . Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron 2004; 44: 59–73.

    Article  CAS  PubMed  Google Scholar 

  57. Song M, Giza J, Proenca CC, Jing D, Elliott M, Dincheva I et al. Slitrk5 mediates BDNF-dependent TrkB receptor trafficking and signaling. Dev Cell 2015; 33: 690–702.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Anastasia A, Deinhardt K, Chao MV, Will NE, Irmady K, Lee FS et al. Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nat Commun 2013; 4: 2490.

    Article  PubMed  Google Scholar 

  59. Dincheva I, Glatt CE, Lee FS . Impact of the BDNF Val66Met polymorphism on cognition: implications for behavioral genetics. Neuroscientist 2012; 18: 439–451.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Mizui T, Ishikawa Y, Kumanogoh H, Lume M, Matsumoto T, Hara T et al. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proc Natl Acad Sci USA 2015; 112: E3067–E3074.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Ninan I, Bath KG, Dagar K, Perez-Castro R, Plummer MR, Lee FS et al. The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. J Neurosci 2010; 30: 8866–8870.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Zorner B, Wolfer DP, Brandis D, Kretz O, Zacher C, Madani R et al. Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than ‘depressive’. Biol Psychiatry 2003; 54: 972–982.

    Article  CAS  PubMed  Google Scholar 

  63. Cosgrove VE, Kelsoe JR, Suppes T . Toward a valid animal model of bipolar disorder: how the research domain criteria help bridge the clinical-basic science divide. Biol Psychiatry 2016; 79: 62–70.

    Article  PubMed  Google Scholar 

  64. O'Tuathaigh CM, Kirby BP, Moran PM, Waddington JL . Mutant mouse models: genotype–phenotype relationships to negative symptoms in schizophrenia. Schizophr Bull 2010; 36: 271–288.

    Article  PubMed  Google Scholar 

  65. Chen G, Henter ID, Manji HK . Partial rodent genetic models for bipolar disorder. Curr Top Behav Neurosci 2011; 5: 89–106.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Umemori J, Takao K, Koshimizu H, Hattori S, Furuse T, Wakana S et al. ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response. BMC Res Notes 2013; 6: 203.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Schmeisser MJ . Translational neurobiology in Shank mutant mice—model systems for neuropsychiatric disorders. Ann Anat 2015; 200: 115–117.

    Article  PubMed  Google Scholar 

  68. Shaltiel G, Maeng S, Malkesman O, Pearson B, Schloesser RJ, Tragon T et al. Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania. Mol Psychiatry 2008; 13: 858–872.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Han K, Holder JL Jr, Schaaf CP, Lu H, Chen H, Kang H et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature 2013; 503: 72–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This study was funded by the Lundbeck Foundation (to AN, SG), the Rochester Epidemiology Project (grant number R01 AG034676) (to AN), Danish Agency for Science Technology and Innovation (DAGMAR) (to AN) and Danish Council for Independent Research Sapere Aude starting grant (grant number DFF 4183-00604) (to SG). Professor Joel Gelernter (Yale University School of Medicine) provided helpful comments. Anja Aagaard and Benedicte Vestergaard are thanked for excellent technical assistance.

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  1. S Glerup and U Bolcho: These authors share first authorship.

Authors and Affiliations

  1. The Lundbeck Foundation Research Center MIND, Danish Research Institute of Translational Neuroscience DANDRITE— Nordic EMBL Partnership for Molecular Medicine, Aarhus C, Denmark

    S Glerup, U Bolcho, S Mølgaard, S Bøggild, C B Vaegter, P L Ovesen, L F Pedersen, M Kjolby, H Login, O M Andersen & A Nykjaer

  2. Department of Biomedicine, Aarhus University, Aarhus C, Denmark

    S Glerup, U Bolcho, S Mølgaard, S Bøggild, C B Vaegter, J L Nieto-Gonzalez, P L Ovesen, L F Pedersen, A N Fjorback, M Kjolby, H Login, M M Holm, O M Andersen & A Nykjaer

  3. Interdepartmental Neuroscience Program and Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA

    A H Smith

  4. Department of Psychiatry, VAT CT Healthcare Center, and Yale School of Medicine, New Haven, CT, USA

    A H Smith

  5. MIND Center, Stereology and Electron Microscopy Laboratory, Aarhus University, Aarhus C, Denmark

    J R Nyengaard

  6. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

    T E Willnow

  7. Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

    K Jensen

  8. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

    A Nykjaer

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  1. S Glerup
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Glerup, S., Bolcho, U., Mølgaard, S. et al. SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Mol Psychiatry 21, 1740–1751 (2016). https://doi.org/10.1038/mp.2016.108

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