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Re-evaluating evolution in the HIV reservoir

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Figure 1: For the first six months of ART, the persistent latent reservoir makes up a minority of sampled sequences.
Figure 2: Simulated decay of labile infected cell population creates misleading appearance of viral replication and evolution in first six months of treatment.

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Authors and Affiliations

Authors

Contributions

Wrote the manuscript: D.I.S.R., A.L.H., S.B.L., R.F.S. Simulations and phylogenetic analyses: D.I.S.R., A.L.H., R.F.S. Estimation of labile compartments: S.B.L., R.F.S.

Corresponding author

Correspondence to Robert F. Siliciano.

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The authors declare no competing financial interests.

Extended data figures and tables

Extended Data Table 1 Analysis of post-treatment simulated samples based on sequences obtained before treatment14

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Supplementary Data

This file contains Supplementary Table 2. (XLSX 3036 kb)

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Rosenbloom, D., Hill, A., Laskey, S. et al. Re-evaluating evolution in the HIV reservoir. Nature 551, E6–E9 (2017). https://doi.org/10.1038/nature24634

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