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GSK-3β sets Snail's pace

Nature Cell Biology volume 6, pages 913–915 (2004)Cite this article

Snail, a transcription factor that promotes epithelial-to-mesenchymal transitions during development, has also been implicated in human cancer. A new mechanism in which GSK-3β phosphorylation regulates the rate of Snail protein degradation may provide insight into invasion and the metastatic progression of tumours.

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Figure 1: GSK-3β phosphorylation consensus sites in Snail.
Figure 2: Multiple levels of Snail regulation.

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Authors and Affiliations

  1. the MRC Laboratory for Molecular Cell Biology & Cell Biology Unit, University College London, Gower Street, London, WC1E 6BT, UK

    Karni Schlessinger & Alan Hall

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  1. Karni Schlessinger
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  2. Alan Hall
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Schlessinger, K., Hall, A. GSK-3β sets Snail's pace. Nat Cell Biol 6, 913–915 (2004). https://doi.org/10.1038/ncb1004-913

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