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Pumilio turns on microRNA function

Nature Cell Biology volume 12, pages 928–929 (2010)Cite this article

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Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3′ untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells.

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Figure 1: Pumilio-mediated regulation of p27 silencing by miR-221/miR-222.

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  1. Department of Biological Chemistry and Molecular Pharmacology, Robinson Triboulet and Richard I. Gregory are in the Stem Cell Program, Children's Hospital Boston, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02115, USA.,

    Robinson Triboulet & Richard I. Gregory

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  1. Robinson Triboulet
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  2. Richard I. Gregory
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Correspondence to Richard I. Gregory.

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Triboulet, R., Gregory, R. Pumilio turns on microRNA function. Nat Cell Biol 12, 928–929 (2010). https://doi.org/10.1038/ncb1010-928

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