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  • Review Article
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Nuclear actin and myosins: Life without filaments

Nature Cell Biology volume 13, pages 1282–1288 (2011)Cite this article

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A Corrigendum to this article was published on 29 May 2015

A Corrigendum to this article was published on 29 May 2015

This article has been updated

Abstract

Actin and myosin are major components of the cell cytoskeleton, with structural and regulatory functions that affect many essential cellular processes. Although they were traditionally thought to function only in the cytoplasm, it is now well accepted that actin and multiple myosins are found in the nucleus. Increasing evidence on their functional roles has highlighted the importance of these proteins in the nuclear compartment.

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Figure 1: The roles of actin in the nucleus.
Figure 2: Myosin in the nucleus.
Figure 3: Actin and myosins in transcription.

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Change history

  • 29 April 2015

    In the version of this Review originally published the authors inadvertently omitted a key reference. This has now been added to the caption of Fig. 3 in the online version: 'The actin-binding protein WASP has been discovered in the nucleus and modulates transcription independently or with the ARP2/3 complex97.' 97. Taylor, M. D. et al. Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome. Sci. Transl. Med. 2, 37ra44 (2010).

  • 14 May 2015

    In the version of this Review originally published reference 34 should have appeared in the caption of Fig. 3: 'The actin-binding protein WASP has been discovered in the nucleus and modulates transcription independently or with the ARP2/3 complex34,97.' This has been corrected in the online versions of the Review.

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Acknowledgements

Supported by a grant from the National Institutes of Health (R01GM080587) to P. de L.

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  1. Primal de Lanerolle and Leonid Serebryannyy are in the Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois 60612, USA,

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de Lanerolle, P., Serebryannyy, L. Nuclear actin and myosins: Life without filaments. Nat Cell Biol 13, 1282–1288 (2011). https://doi.org/10.1038/ncb2364

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