Conformational targeting enabled the creation of a ubiquitin variant that specifically inhibits the deubiquitinating enzyme ubiquitin-specific protease 7 (also known as HAUSP). Generation of such tools is essential to unravel the complexities of ubiquitin signaling, but how general is this approach?
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Sixma, T. Making ubiquitin specific. Nat Chem Biol 9, 10–11 (2013). https://doi.org/10.1038/nchembio.1143
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DOI: https://doi.org/10.1038/nchembio.1143
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