The GTPase switch is a versatile molecular device used by many proteins, such as the small GTPases, to regulate an astounding number of functions. Although the basics of the guanine nucleotide cycle are now well established, the next challenge is to reach an integrated view of how these proteins use it to orchestrate signaling pathways.
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Acknowledgements
This work was supported by the Centre National de la Recherche Scientifique, the Association pour la Recherche contre le Cancer and the Agence Nationale de la Recherche.
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Cherfils, J., Zeghouf, M. Chronicles of the GTPase switch. Nat Chem Biol 7, 493–495 (2011). https://doi.org/10.1038/nchembio.608
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DOI: https://doi.org/10.1038/nchembio.608
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