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Therapeutic potential of targeting IL-17

Nature Immunology volume 13, pages 1022–1025 (2012)Cite this article

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Abstract

A June 2012 meeting in Dublin, Ireland, showcased advances in the understanding of the role of IL-17 and related cytokines in host immunity and how these cytokines have been successfully targeted for the treatment of autoimmunity.

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Figure 1: Cells that secrete cytokines of the IL-17 family and their receptors.
Figure 2: Influence of therapeutic antibodies on TH1 and TH17 pathways.

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Acknowledgements

We thank all presenters at the conference for their contributions and apologize to all whose work was not included because of space constraints. The conference was held under the auspices of the International Cytokine Society at the Trinity Biomedical Sciences Institute, Trinity College, Dublin, and was organized by K. Mills and D. Cua, with assistance from Julie-Ann O'Reilly. We thank the following sponsors: Science Foundation Ireland, BioLegend, eBioscience, BioRad, Randox, Abcam, MabTech, PeproTech, R&D Systems, Pfizer, Abbott, Amgen, Cell Press/Elsevier, MedImmune, Merck Sharp & Dohme and the Irish Tourist Board.

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Authors and Affiliations

  1. Sarah A. Jones, Caroline E. Sutton and Kingston H.G. Mills are with the School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.,

    Sarah A Jones, Caroline E Sutton & Kingston H G Mills

  2. Daniel Cua is with Merck Research Laboratory, Palo Alto, California, USA.,

    Daniel Cua

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  1. Sarah A Jones
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  2. Caroline E Sutton
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  3. Daniel Cua
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  4. Kingston H G Mills
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Correspondence to Kingston H G Mills.

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Competing interests

K.H.G.M. is the cofounder of and a shareholder in Opsona Therapeutics and TriMod Therapeutics, which are start-up companies involved in the development of immunotherapeutics. D.C. is an employee of Merck.

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Jones, S., Sutton, C., Cua, D. et al. Therapeutic potential of targeting IL-17. Nat Immunol 13, 1022–1025 (2012). https://doi.org/10.1038/ni.2450

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