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Can DCs be distinguished from macrophages by molecular signatures?

Nature Immunology volume 14, pages 187–189 (2013)Cite this article

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An Erratum to this article was published on 19 July 2013

This article has been updated

To the Editor:

An article from the Immunological Genome (ImmGen) Consortium published in Nature Immunology focuses on the differentiation of dendritic cells (DCs) in the mouse and efforts to distinguish those cells from macrophages1. In that article, Miller et al. report a small set of markers whose expression is restricted to or shows higher expression in DCs relative to their expression in four prototypical tissue macrophage populations1. Those findings contrast to our own observations obtained with large microarray data sets of macrophages and DCs2,3, and we wish to provide a different perspective.

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Figure 1: Sample-to-sample clustering of expression profiles of macrophage and DCs.

Change history

  • 22 April 2013

    In the version of this article initially published, the first URL in the third paragraph was incorrect. The correct URL is http://www.macrophages.com/HumeNI2013. The error has been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. The Roslin Institute, University of Edinburgh, Edinburgh, UK

    David A Hume, Neil Mabbott, Sobia Raza & Tom C Freeman

Authors
  1. David A Hume
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  2. Neil Mabbott
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  3. Sobia Raza
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  4. Tom C Freeman
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Correspondence to David A Hume.

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Hume, D., Mabbott, N., Raza, S. et al. Can DCs be distinguished from macrophages by molecular signatures?. Nat Immunol 14, 187–189 (2013). https://doi.org/10.1038/ni.2516

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