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CD8 and B cell memory: same strategy, same signals

Generation of B cell memory requires CD4+ T cell help and involves triggering of CD40 in target B cells. Several recent studies indicate that similar signals are involved in the generation of memory CD8+ T lymphocytes.

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Figure 1: Comparison of B cell and CD8+ T cell differentiation into memory cells.

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Correspondence to Benedita Rocha.

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Tanchot, C., Rocha, B. CD8 and B cell memory: same strategy, same signals. Nat Immunol 4, 431–432 (2003). https://doi.org/10.1038/ni0503-431

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