Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Understanding human immune function using the resources from the Human Functional Genomics Project

Nature Medicine volume 22, pages 831–833 (2016)Cite this article

Subjects

To the Editor:

The human immune system is represented by a complex network of organs, tissues, cells and molecules that evolved primarily to protect the host against infections. However, the immune system influences much more than host defense: it has crucial roles in immune surveillance of malignancies, it inflicts damage in the context of autoimmune and autoinflammatory diseases and it affects host metabolism and aging.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kumar, V., Wijmenga, C. & Xavier, R.J. Curr. Opin. Immunol. 31, 51–57 (2014).

    Article  CAS  Google Scholar 

  2. Ye, C.J. et al. Science 345, 1254665 (2014).

    Article  Google Scholar 

  3. Kaiser, J. Science 349, 1433 (2015).

    Article  CAS  Google Scholar 

  4. Fairfax, B.P. et al. Science 343, 1246949 (2014).

    Article  Google Scholar 

  5. Lee, M.N. et al. Science 343, 1246980 (2014).

    Article  Google Scholar 

  6. Netea, M.G., Wijmenga, C. & O'Neill, L.A.J. Nat. Immunol. 13, 535–542 (2012).

    Article  CAS  Google Scholar 

  7. Li, Y. et al. Nat. Med. 22, 950–958 (2016).

    Google Scholar 

  8. Thomas, S. et al. Clin. Immunol. 157, 277–293 (2015).

    Article  CAS  Google Scholar 

  9. Swertz, M.A. et al. BMC Bioinformatics 11, S12 (2010).

    Article  Google Scholar 

  10. Zhernakova, A. et al. Science 352, 565–569 (2016).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We would like to acknowledge the additional HFGP collaborating institutes as of June 2016: 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, Romania, University of Medicine Craiova, Romania and Kilimanjaro Christian Medical University College, Moshi, Tanzania. The HFGP is supported by ERC Grants (to M.G.N. and C.W.), the Spinoza Prize (M.G.N., C.W.), the IN-CONTROL Netherlands Heart Institute Grant, the Dutch Digestive Diseases Foundation and Dutch Arthritis Foundation Grants, US National Institutes of Health grants and the Helmsley Charitable Trust (to R.J.X).

Author information

Authors and Affiliations

  1. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands

    Mihai G Netea, Leo A B Joosten, Marije Oosting, Sanne Smeekens, Martin Jaeger, Rob ter Horst, Richard Notebaart, Norman Pavelka, Rahajeng N Tunjungputri, Wouter van de Heijden, Kiki Schraa, Romana Netea-Maier, Jan Smit, Quirijn de Mast, Frank van de Veerdonk, Bart Jan Kullberg, Cees Tack, Inge van de Munckhof, Joost Rutten, Jacqueline van der Graaf, Jos W M van der Meer, Charles A Dinarello & Andre van der Ven

  2. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

    Yang Li, Vinod Kumar, Raul Raul Aguirre-Gamboa, Morris A Swertz, Lude Franke, Marten Hofker, Iris Jonkers, Mathieu Platteel, Astrid Maatman, Jingyuan Fu, Alexandra Zhernakova & Cisca Wijmenga

  3. Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA

    Melanie Schirmer, Hera Vlamakis, Eric A Franzosa, Aylwin Ng, Daniel Graham, Kara Lassen, Curtis Huttenhouwer & Ramnik J Xavier

  4. Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA

    Melanie Schirmer, Hera Vlamakis, Eric A Franzosa, Aylwin Ng, Daniel Graham, Kara Lassen, Curtis Huttenhouwer & Ramnik J Xavier

  5. Singapore Immunology Network (SIgN), A-STAR, Singapore

    Norman Pavelka

  6. Department of Infectious Diseases, University of Colorado, Denver, Denver, Colorado, USA

    Charles A Dinarello

  7. Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, the Netherlands

    Hans Koenen & Irma Joosten

Authors
  1. Mihai G Netea
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Leo A B Joosten
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vinod Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Marije Oosting
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sanne Smeekens
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Martin Jaeger
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Rob ter Horst
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Melanie Schirmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Hera Vlamakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Richard Notebaart
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Norman Pavelka
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Raul Raul Aguirre-Gamboa
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Morris A Swertz
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Rahajeng N Tunjungputri
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Wouter van de Heijden
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Eric A Franzosa
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Aylwin Ng
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Daniel Graham
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Kara Lassen
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Kiki Schraa
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Romana Netea-Maier
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Jan Smit
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Quirijn de Mast
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. Frank van de Veerdonk
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. Bart Jan Kullberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. Cees Tack
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. Inge van de Munckhof
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. Joost Rutten
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. Jacqueline van der Graaf
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. Lude Franke
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. Marten Hofker
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. Iris Jonkers
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. Mathieu Platteel
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. Astrid Maatman
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. Jingyuan Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  37. Alexandra Zhernakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  38. Jos W M van der Meer
    View author publications

    You can also search for this author in PubMed Google Scholar

  39. Charles A Dinarello
    View author publications

    You can also search for this author in PubMed Google Scholar

  40. Andre van der Ven
    View author publications

    You can also search for this author in PubMed Google Scholar

  41. Curtis Huttenhouwer
    View author publications

    You can also search for this author in PubMed Google Scholar

  42. Hans Koenen
    View author publications

    You can also search for this author in PubMed Google Scholar

  43. Irma Joosten
    View author publications

    You can also search for this author in PubMed Google Scholar

  44. Ramnik J Xavier
    View author publications

    You can also search for this author in PubMed Google Scholar

  45. Cisca Wijmenga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mihai G Netea.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Netea, M., Joosten, L., Li, Y. et al. Understanding human immune function using the resources from the Human Functional Genomics Project. Nat Med 22, 831–833 (2016). https://doi.org/10.1038/nm.4140

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.4140

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing