The transcription factor STAT3 is overactive in many tumors and has attracted attention as a drug target. But in vivo evidence suggesting that inhibiting STAT3 could counteract cancer has been incomplete. The picture in the whole animal now begins to clarify, and it bodes well for this approach (pages 623–629).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad
Laboratory Animal Research Open Access 21 December 2019
-
Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer
World Journal of Surgical Oncology Open Access 19 November 2018
-
Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells
Scientific Reports Open Access 12 December 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Yu, H. & Jove, R. Nat. Rev. Cancer 4, 97–105 (2004).
Levy, D. & Darnell, J.E., Jr. Nat. Rev. Mol. Cell Biol. 3, 651–662 (2002).
Darnell, J.E., Jr. Nat. Rev. Cancer 2, 740–749 (2002).
Chan, K.S. J. Clin. Invest. 114, 720–728 (2004).
Chiarle, R. et al. Nat. Med. 11, 623–629 (2005).
Bromberg, J.F. et al. Cell 98, 295–303 (1999).
Yoshikawa, H. et al. Nat. Genet. 28, 29–35 (2001).
He, B. et al. Proc. Natl. Acad. Sci. USA 100, 14133–14138 (2003).
Zhang, Q. et al. J. Immunol. 168, 466–474 (2002).
Morris, S.W. Science 263, 1281–1284 (1994).
Xi, S., Gooding, W.E. & Grandis, J.R. Oncogene 24, 970–979 (2005).
Turkson, J. et al. Mol. Cancer Ther. 3, 1533–1542 (2004).
Sun, J. et al. Oncogene 24, 1–10 (2005).
Song, H., Wang, R., Wang, S. & Lin, J. Proc. Natl. Acad. Sci. USA 102, 4700–4705 (2005).
Zhong, M. et al. Proc. Natl. Acad. Sci. USA 102, 3966–3971 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Darnell, J. Validating Stat3 in cancer therapy. Nat Med 11, 595–596 (2005). https://doi.org/10.1038/nm0605-595
Issue Date:
DOI: https://doi.org/10.1038/nm0605-595
This article is cited by
-
JAK–STAT pathway targeting for the treatment of inflammatory bowel disease
Nature Reviews Gastroenterology & Hepatology (2020)
-
Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad
Laboratory Animal Research (2019)
-
Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer
World Journal of Surgical Oncology (2018)
-
IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling
Journal of Translational Medicine (2017)
-
Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells
Scientific Reports (2017)