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Vorinostat

Nature Reviews Drug Discovery volume 6, pages 21–22 (2007)Cite this article

Abstract

Vorinostat (Zolinza; Merck) was approved by the US FDA in October 2006 for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies. It is the first in a new class of anticancer agents that inhibit histone deacetylases, which have a key role in the epigenetic regulation of gene expression.

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Figure 1: Chromatin structure and transcriptional activity.
Figure 2: Vorinostat.

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Authors and Affiliations

  1. the Division of Hematology/Oncology, Virginia Commonwealth University/Medical College of Virginia, Richmond, 23298, Virginia, USA

    Steven Grant

  2. IMS Health, 7 Harewood Avenue, London, NW1 6JB, UK

    Chris Easley

  3. Nature Reviews Drug Discovery,

    Peter Kirkpatrick

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  1. Steven Grant
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  2. Chris Easley
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  3. Peter Kirkpatrick
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Grant, S., Easley, C. & Kirkpatrick, P. Vorinostat. Nat Rev Drug Discov 6, 21–22 (2007). https://doi.org/10.1038/nrd2227

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  • DOI: https://doi.org/10.1038/nrd2227

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