Abstract
New targets for pharmacological interventions are of great importance to combat the epidemic of obesity. Brown adipose tissue could potentially represent one such target. Unlike white adipose tissue, brown adipose tissue has the ability to dissipate energy by producing heat rather than storing it as triglycerides. In small mammals, the presence of active brown adipose tissue is pivotal for the maintenance of body temperature and possibly to protect against the detrimental effects of surplus energy intake. Animal studies have shown that expansion and/or activation of brown adipose tissue counteracts diet-induced weight gain and related disorders such as type 2 diabetes mellitus. Several independent studies have now confirmed the presence of functional brown adipose tissue in adult humans, for whom this tissue is probably metabolically beneficial given its association with both low BMI and low total adipose tissue content. Over the past few years, knowledge of the transcriptional control and development of brown adipose tissue has increased substantially. Thus, several possible targets that may be useful for the expansion and/or activation of this tissue by pharmacological means have been identified. Whether or not brown adipose tissue will be useful in the battle against obesity remains to be seen. However, this possibility is certainly well worth exploring.
Key Points
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The brown adipose organ has the capacity to consume energy by producing heat to defend an organism against a cold environment
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Several studies have shown that metabolically active brown adipose tissue is present in notable amounts in healthy adults
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The presence of brown adipose tissue in adults is inversely correlated with both BMI and percentage of body adipose tissue
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Drugs aimed at expanding and/or activating brown adipose tissue are of possible interest for the treatment of obesity and obesity-related diseases like type 2 diabetes mellitus
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Acknowledgements
We apologize to all colleagues who have been cited only cursorily, or have not been cited due to space constraints. M. E. Lidell and S. Enerbäck are supported by grants from the Söderberg Foundation, the Swedish Research Council (grant K2005-32BI-15,324-01A), the Arne and IngaBritt Lundberg Foundation, the Knut and Alice Wallenberg Foundation and the Swedish Foundation for Strategic Research through the Center for Cardiovascular and Metabolic Research.
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Lidell, M., Enerbäck, S. Brown adipose tissue—a new role in humans?. Nat Rev Endocrinol 6, 319–325 (2010). https://doi.org/10.1038/nrendo.2010.64
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DOI: https://doi.org/10.1038/nrendo.2010.64
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