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Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response

Nature Reviews Immunology volume 7, pages 238–243 (2007)Cite this article

Abstract

Cells can extend the limits of their transcriptome by using proteins captured from other cells. Through an exchange of specific proteins, tools and information can be shared to establish integrated communities of cells that are better able to coordinate stages of an immune response. Transferred proteins can also contribute to pathology by allowing, for example, infection of cell types not otherwise infected. Here, I present the case for considering the intercellular transfer of cell-surface proteins between immune cells as commonplace and important.

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Figure 1: Mechanisms for intercellular protein transfer between immune cells.
Figure 2: Potential functions for the intercellular transfer of cell-surface proteins between immune cells.

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Acknowledgements

I thank P. Höglund and members of my laboratory for critical reading of the manuscript. I thank G. Williams for influential discussions on the mechanisms involved in the intercellular transfer of cell-surface proteins. I am also grateful to others who have worked with me in this research area, including L. Carlin, P. Eissmann, F. McCann, B. Önfelt and B. Vanherberghen. I am grateful to D. Bacon for helping construct the figures. My laboratory is financed by the Medical Research Council, the Biotechnology and Biological Science Research Council, and a Lister Research Institute Prize Fellowship.

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  1. Daniel M. Davis is at the Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK. d.davis@imperial.ac.uk,

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Davis, D. Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response. Nat Rev Immunol 7, 238–243 (2007). https://doi.org/10.1038/nri2020

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