The structure of the dimeric replication initiator of pPS10 reveals that secondary structure remodeling of chameleon sequences defines the monomer-dimer oligomerization state of the protein. Together with an unanticipated dimerization interface, this result will steer thinking in the field and influence strategies to control spread of virulence and antibiotic resistance genes that are often plasmid-encoded.
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Forest, K., Filutowicz, M. Remodeling of replication initiator proteins. Nat Struct Mol Biol 10, 496–498 (2003). https://doi.org/10.1038/nsb0703-496
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DOI: https://doi.org/10.1038/nsb0703-496
