Since the discovery of Prp16, a spliceosomal ATPase that alters the fidelity of splicing, many other ATPases associated with the spliceosome have been postulated to work similarly. The finding that Prp22, a DEAH-box ATPase, functions as a fidelity factor for the second step of splicing supports this hypothesis.
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References
Schwer,B. Nat. Struct. Biol. 8, 113–116 (2001).
Mayas, R.M., Maita, H. & Staley, J.P. Nat. Struct. Mol. Biol. 13, 482–490 (2006).
Burgess, S., Couto, J.R. & Guthrie, C. Cell 60, 705–717 (1990).
Burgess, S.M. & Guthrie, C. Trends Biochem. Sci. 18, 381–384 (1993).
Couto, J.R., Tamm, J., Parker, R. & Guthrie, C. Genes Dev. 1, 445–455 (1987).
Schwer, B. & Guthrie, C. Nature 349, 494–499 (1991).
Villa, T. & Guthrie, C. Genes Dev. 19, 1894–1904 (2005).
Konarska, M.M. & Query, C.C. Genes Dev. 19, 2255–2260 (2005).
Company, M., Arenas, J. & Abelson, J. Nature 349, 487–493 (1991).
Hönig, A., Auboeuf, D., Parker, M.M., O'Malley, B.W. & Berget, S.M. Mol. Cell. Biol. 22, 5698–5707 (2002).
Schwer, B. & Gross, C.H. EMBO J. 17, 2086–2094 (1998).
Schneider, S., Campodonico, E. & Schwer, B. J. Biol. Chem. 279, 8617–8626 (2004).
Brow, D.A. Annu. Rev. Genet. 36, 333–360 (2002).
Grainger, R.J. & Beggs, J.D. RNA 11, 533–557 (2005).
Chen, J.Y. et al. Mol. Cell 7, 227–232 (2001).
Perriman, R., Barta, I., Voeltz, G.K., Abelson, J. & Ares, M. Jr. Proc. Natl Acad. Sci. USA 100, 13857–13862 (2003).
Puoti, A. & Kimble, J. Proc. Natl Acad. Sci. USA 97, 3276–3281 (2000).
Belfiore, M. et al. RNA 8, 725–739 (2002).
Park, J.W., Parisky, K., Celotto, A.M., Reenan, R.A. & Graveley, B.R. Proc. Natl Acad. Sci. USA 101, 15974–15979 (2004).
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Query, C., Konarska, M. Splicing fidelity revisited. Nat Struct Mol Biol 13, 472–474 (2006). https://doi.org/10.1038/nsmb0606-472
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DOI: https://doi.org/10.1038/nsmb0606-472
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