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Humanized immune system mouse models: progress, challenges and opportunities

Nature Immunology volume 20, pages 770–774 (2019)Cite this article

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On 18 December 2018, the National Institute of Allergy and Infectious Diseases convened a workshop entitled ‘Recent Advances and Opportunities in the Development and Use of Humanized Immune System Mouse Models’.

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Fig. 1: Humanized mouse models.
Fig. 2: Areas that require development and optimization in HIS mice.

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Acknowledgements

We thank K. Abraham, A. Augustine and J. Breen for critical reading of the manuscript.

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Authors and Affiliations

  1. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

    Todd M. Allen

  2. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA

    Michael A. Brehm

  3. Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Institutes of Health, Rockville, MD, USA

    Sandra Bridges & Brigitte Sanders-Beer

  4. Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA

    Stacy Ferguson & Mercy PrabhuDas

  5. Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA

    Priti Kumar

  6. Office of Research Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, Bethesda, MD, USA

    Oleg Mirochnitchenko

  7. The Jackson Laboratory, Farmington, CT, USA

    Karolina Palucka

  8. Department of Immunology and Microbiology, University of Colorado, Aurora, CO, USA

    Roberta Pelanda

  9. The Jackson Laboratory, Bar Harbor, ME, USA

    Leonard D. Shultz

  10. University of North Carolina, Chapel Hill, Chapel Hill, NC, USA

    Lishan Su

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  1. Todd M. Allen
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Corresponding author

Correspondence to Mercy PrabhuDas.

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Allen, T.M., Brehm, M.A., Bridges, S. et al. Humanized immune system mouse models: progress, challenges and opportunities. Nat Immunol 20, 770–774 (2019). https://doi.org/10.1038/s41590-019-0416-z

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