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NEURODEGENERATION

A traffic jam leads to Lewy bodies

Nature Neuroscience volume 22, pages 1043–1045 (2019)Cite this article

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Shahmoradian and colleagues report that the structure of Lewy bodies in Parkinson’s disease consists of α-synuclein and lipid vesicle clusters instead of the long-assumed amyloid fibril core. This finding has implications for our understanding of the underlying pathogenesis of synucleinopathies.

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Fig. 1: Different models of αSyn dysfunction in disease.

References

  1. Spillantini, M. G. et al. Nature 388, 839–840 (1997).

    Article  CAS  Google Scholar 

  2. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M. & Goedert, M. Proc. Natl. Acad. Sci. USA 95, 6469–6473 (1998).

    Article  CAS  Google Scholar 

  3. Shahmoradian, S.H. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-019-0423-2 (2019).

  4. Braak, H. et al. Neurobiol. Aging 24, 197–211 (2003).

    Article  Google Scholar 

  5. Fortin, D. L., Nemani, V. M., Nakamura, K. & Edwards, R. H. Mov. Disord. 25 Suppl 1, S21–S26 (2010).

    Article  Google Scholar 

  6. Davidson, W. S., Jonas, A., Clayton, D. F. & George, J. M. J. Biol. Chem. 273, 9443–9449 (1998).

    Article  CAS  Google Scholar 

  7. Sidransky, E., Samaddar, T. & Tayebi, N. Neurology 73, 1424–1425; author reply 1425–1426 (2009).

  8. Fanning, S. et al. Mol. Cell 73, 1001–1014.e8 (2019).

    Article  CAS  Google Scholar 

  9. Wang, L. et al. Curr. Biol. 24, 2319–2326 (2014).

    Article  CAS  Google Scholar 

  10. Cooper, A. A. et al. Science 313, 324–328 (2006).

    Article  CAS  Google Scholar 

  11. Dettmer, U. et al. Hum. Mol. Genet. 26, 3466–3481 (2017).

    Article  CAS  Google Scholar 

  12. Galvagnion, C. et al. Nat. Chem. Biol. 11, 229–234 (2015).

    Article  CAS  Google Scholar 

  13. Rovere, M., Sanderson, J. B., Fonseca-Ornelas, L., Patel, D. S. & Bartels, T. FEBS Lett. 592, 1464–1472 (2018).

    Article  CAS  Google Scholar 

  14. Kim, S. et al. Proc. Natl. Acad. Sci. USA 115, 798–803 (2018).

    Article  CAS  Google Scholar 

  15. Nuber, S. et al. Neuron 100, 75–90.e5 (2018).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Dementia Research Institute, University College London, London, United Kingdom

    Tim Bartels

  2. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA

    Tim Bartels

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  1. Tim Bartels
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Correspondence to Tim Bartels.

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Bartels, T. A traffic jam leads to Lewy bodies. Nat Neurosci 22, 1043–1045 (2019). https://doi.org/10.1038/s41593-019-0435-y

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