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Chronic Lymphocytic Leukemia

Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression

Leukemia volume 20, pages 1080–1088 (2006)Cite this article

Abstract

Lipoprotein lipase (LPL) is a prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL) related to immunoglobulin VH gene (IgVH)mutational status. We determined gene expression profiles using Affymetrix U133A GeneChips in two groups of B-CLLs selected for either high (‘LPL+’, n=10) or low (‘LPL−’, n=10) LPL mRNA expression. Selected genes were verified by real-time PCR in an extended patient cohort (n=42). A total of 111 genes discriminated LPL+ from LPL− B-CLLs. Of these, the top three genes associated with time to first treatment were Septin10, DMD and Gravin (P⩽0.01). The relationship of LPL+ and LPL− B-CLL gene expression signatures to 52 tissues was statistically analyzed. The LPL+ B-CLL expression signature, represented by 64 genes was significantly related to fat, muscle and PB dendritic cells (P<0.001). Exploration of microarray data to define functional alterations related to the biology of LPL+ CLL identified two functional modules, fatty acid degradation and MTA3 signaling, as being altered with higher statistical significance. Our data show that LPL+ B-CLL cells have not only acquired gene expression changes in fat and muscle-associated genes but also in functional pathways related to fatty acid degradation and signaling which may ultimately influence CLL biology and clinical outcome.

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Acknowledgements

We are greatly indebted to G.Kostner and R. Zechner for helpful discussions. This study is supported by grants from the Austrian National Bank (Grant no. 9964), the Austrian Human Genome Project (‘C.h.i.l.d’) (UJ), the Center of Molecular Medicine (CeMM) of the Austrian Academy of Sciences (no. 20010 to UJ and no. 20030 to WP), Corixa Co., Seattle (AG), DFG (STI 296/1), Sander (2001.04.02) and Fresenius (CLL4) (DK, AK, HD, SS)

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  1. M Bilban and D Heintel: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

    M Bilban & O Wagner

  2. Ludwig Boltzmann Institute for Clinical and Experimental Oncology, Vienna, Austria

    M Bilban, M M Auer, M Shehata, C Zielinski, A Gaiger, O Wagner & U Jäger

  3. Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna,

    D Heintel, M M Auer, E Porpaczy, B Kainz, M Shehata, A Gaiger & U Jäger

  4. Vienna, Austria

    D Heintel, M M Auer, E Porpaczy, B Kainz, M Shehata, A Gaiger & U Jäger

  5. Department of Statistics and Probability Theory, Vienna University of Technology, Vienna, Austria

    T Scharl & T Woelfel

  6. Department of Internal Medicine III, University of Ulm, Ulm, Germany

    A Kröber & S Stilgenbauer

  7. Department of Medicine, Harvard Medical School, Boston, MA, USA

    V J Carey & A Gaiger

  8. Institute of Immunology, Medical University of Vienna, Vienna, Austria

    W Pickl

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Bilban, M., Heintel, D., Scharl, T. et al. Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression. Leukemia 20, 1080–1088 (2006). https://doi.org/10.1038/sj.leu.2404220

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