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Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia

Molecular Psychiatry volume 13, pages 147–161 (2008)Cite this article

Abstract

In subjects with schizophrenia, impairments in working memory are associated with dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to be due, at least in part, to abnormalities in γ-aminobutyric acid (GABA)-mediated inhibitory circuitry. To test the hypothesis that altered GABA-mediated circuitry in the DLPFC of subjects with schizophrenia reflects expression changes of genes that encode selective presynaptic and postsynaptic components of GABA neurotransmission, we conducted a systematic expression analysis of GABA-related transcripts in the DLPFC of 14 pairs of schizophrenia and age-, sex- and post-mortem interval-matched control subjects using a customized DNA microarray with enhanced sensitivity and specificity. Subjects with schizophrenia exhibited expression deficits in GABA-related transcripts encoding (1) presynaptic regulators of GABA neurotransmission (67 kDa isoform of glutamic acid decarboxylase (GAD67) and GABA transporter 1), (2) neuropeptides (somatostatin (SST), neuropeptide Y (NPY) and cholecystokinin (CCK)) and (3) GABAA receptor subunits (α1, α4, β3, γ2 and δ). Real-time qPCR and/or in situ hybridization confirmed the deficits for six representative transcripts tested in the same pairs and in an extended cohort, respectively. In contrast, GAD67, SST and α1 subunit mRNA levels, as assessed by in situ hybridization, were not altered in the DLPFC of monkeys chronically exposed to antipsychotic medications. These findings suggest that schizophrenia is associated with alterations in inhibitory inputs from SST/NPY-containing and CCK-containing subpopulations of GABA neurons and in the signaling via certain GABAA receptors that mediate synaptic (phasic) or extrasynaptic (tonic) inhibition. In concert with previous findings, these data suggest that working memory dysfunction in schizophrenia is mediated by altered GABA neurotransmission in certain DLPFC microcircuits.

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Acknowledgements

This work was supported by NIH grants MH43784 (DAL), MH45156 (DAL), MH067234 (KM) and MH070786 (KM), by an investigator-initiated grant from Eli Lilly (DAL) and by a NARSAD Young Investigator Award (TH). We thank Ms Mary L Brady and Ms Jimette Gilmartin for their assistance in preparing figures and the manuscript.

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  1. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA

    T Hashimoto, D Arion, T Unger, D W Volk, K Mirnics & D A Lewis

  2. Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA

    J G Maldonado-Avilés, H M Morris & D A Lewis

  3. Department of Psychiatry and Vanderbilt Kennedy Center for Human Development Vanderbilt University, Nashville, TN, USA

    K Mirnics

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  1. T Hashimoto
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Correspondence to D A Lewis.

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Hashimoto, T., Arion, D., Unger, T. et al. Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 13, 147–161 (2008). https://doi.org/10.1038/sj.mp.4002011

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