Stable Karyotypes in Epithelial Cancer Cell Lines Despite High Rates of Ongoing Structural and Numerical Chromosomal Instability
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Keywords
structural chromosomal instability
numerical chromosomal instability
karyotypic progression
spectral karyotyping. (20SKY)
comparative genomic hybridization. (20 CGH )
Abbreviations
RER
replication error
SKY
spectral karyotyping
CGH
comparative genomic hybridization
del
deleted chromosome
der
derivative chromosome
TUNEL
TdT-mediated dUTP-X nick end labeling
Composite karyotype
a karyotype with all clonal aberrations listed
Consensus karyotype
a composite karyotype, which includes clonal aberrations detected by SKY, and where the gains and the losses of genetic material are also confirmed by CGH
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Copyright © 2002 Nature Publishing Group. Published by Elsevier Inc.