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The role of c-myc in cellular growth control

Oncogene volume 18, pages 2988–2996 (1999)Cite this article

Abstract

Cell division is coupled to cell growth. Since some c-myc target genes are regulators of cell growth while others function in cell division pathways, c-myc is apparently poised at the interface of these processes. Cell culture systems have shown specific myc-associated growth phenotypes. Increased cell growth precedes DNA synthesis after myc activation in cells expressing myc-estrogen receptor fuson constructs and cells lacking c-myc exhibit a marked loss of protein synthesis. A number of candidate c-myc target genes regulate processes required for cell growth including rRNA transcription and processing, ribosomal protein transcription and translation, and translation initiation. These interactions all have the potential to account for the growth phenotypes in c-myc mutant cells. The ability of translation initiation factors, including eIF4E, to transform cells makes them particularly interesting targets of c-myc. Further evaluation of these target genes will provide important insights into growth control and c-myc's functions in cellular proliferation.

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Acknowledgements

I would like to thank members of the MGH Cancer Center for helpful discussions. I would especially like to acknowledge the intellectual contributions of two fellows from my laboratory who most significantly contributed to the development of the ideas set forth in this review – Drs Michael Polymenis and Igor Rosenwald. Work in the author's laboratory was supported by PHS grants RO1-CA63117 and RO1-CA69069 from the National Institutes of Health to Emmett V Schmidt.

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  1. MGH Cancer Center, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, Massachusetts, USA

    Emmett V Schmidt

  2. Massachusetts General Hospital and the Department of Pediatrics, The Pediatric Service, Harvard Medical School, Fruit Street, Boston, MA 02114, Massachusetts, USA

    Emmett V Schmidt

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Schmidt, E. The role of c-myc in cellular growth control. Oncogene 18, 2988–2996 (1999). https://doi.org/10.1038/sj.onc.1202751

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