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Serine phosphorylation of STATs

Oncogene volume 19, pages 2628–2637 (2000)Cite this article

Abstract

Tyrosine phosphorylation regulates the dimerization of STATs as an essential prerequisite for the establishment of a classical JAK-STAT signaling path. However, most vertebrate STATs contain a second phosphorylation site within their C-termini. The phosphorylated residue in this case is a serine contained within a P(M)SP motif, and in the majority of situations its mutation to alanine alters transcription factor activity. This review addresses recent advances in understanding the regulation of STAT serine phosphorylation, as well as the kinases and other signal transducers implied in this process. The biochemical and biological consequences of STAT serine phosphorylation are discussed.

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Acknowledgements

We thank colleagues for providing preprints of manuscripts for communication of unpublished results. We are grateful to Manuela Baccarini for critical reading of the manuscript. Research in our laboratory is funded by the Austrian research foundation (FWF) through grants P13640-GEN and P-12946-GEN to T Decker.

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  1. Vienna Biocenter, Institute of Microbiology and Genetics, Dr. Bohr-Gasse 9, Vienna, A-1030, Austria

    Thomas Decker & Pavel Kovarik

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Decker, T., Kovarik, P. Serine phosphorylation of STATs. Oncogene 19, 2628–2637 (2000). https://doi.org/10.1038/sj.onc.1203481

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