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Ets factors and regulation of the extracellular matrix

Oncogene volume 19, pages 6464–6471 (2000)Cite this article

Abstract

Ets factors are critical mediators of extracellular matrix (ECM) remodelling. As the spectrum of Ets-regulated target genes widens, so does their role in various pathological and physiological processes. Regulation of matrix degrading proteases by Ets factors in tumor invasion and metastasis is well established. Emerging evidence suggests that they may also play a role in the pathology of autoimmune diseases. Newly characterized Ets target genes such as tenascin-C and collagen type I suggest their role in diseases characterized by aberrant collagen deposition (fibrosis). Ets function is also critical in bone and cartilage development. There is increasing knowledge of the complex regulatory mechanisms involved in transcription of Ets target genes. Ets factors may function as activators or as repressors via association with specific cofactors depending on the promoter context. Signaling pathways can modulate the activation status of Ets factors and their transcriptional partners. Precise understanding of the role of Ets factors in the complex cellular network governing the expression of ECM proteins and the enzymes that degrade them will be a focus of future studies.

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Acknowledgements

This article is dedicated to the memory of Dr Takis S Papas, a very special colleague and friend, whose presence at MUSC broadened my research interest and led to new fruitful collaborations.

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  1. Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29401, South Carolina, USA

    Maria Trojanowska

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Trojanowska, M. Ets factors and regulation of the extracellular matrix. Oncogene 19, 6464–6471 (2000). https://doi.org/10.1038/sj.onc.1204043

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