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The c-Rel transcription factor and B-cell proliferation: a deal with the devil

Oncogene volume 23, pages 2275–2286 (2004)Cite this article

Abstract

Activation of the Rel/NF-κB signal transduction pathway has been associated with a variety of animal and human malignancies. However, among the Rel/NF-κB family members, only c-Rel has been consistently shown to be able to malignantly transform cells in culture. In addition, c-rel has been activated by a retroviral promoter insertion in an avian B-cell lymphoma, and amplifications of REL (human c-rel) are frequently seen in Hodgkin's lymphomas and diffuse large B-cell lymphomas, and in some follicular and mediastinal B-cell lymphomas. Phenotypic analysis of c-rel knockout mice demonstrates that c-Rel has a normal role in B-cell proliferation and survival; moreover, c-Rel nuclear activity is required for B-cell development. Few mammalian model systems are available to study the role of c-Rel in oncogenesis, and it is still not clear what features of c-Rel endow it with its unique oncogenic activity among the Rel/NF-κB family. In any event, REL may provide an appropriate therapeutic target for certain human lymphoid cell malignancies.

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Acknowledgements

Research in our laboratory is supported by National Institutes of Health Grant CA47763 to TDG. M-CL was supported in part by a scholarship from the Ministry of Education, Taiwan; DTS was supported in part by a Predoctoral Fellowship from the Natural Sciences & Engineering Research Council of Canada.

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    Thomas D Gilmore, Demetrios Kalaitzidis, Mei-Chih Liang & Daniel T Starczynowski

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Gilmore, T., Kalaitzidis, D., Liang, MC. et al. The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene 23, 2275–2286 (2004). https://doi.org/10.1038/sj.onc.1207410

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